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We tested the hypothesis that vascular remodeling in the cortex, hippocampus, and thalamus is associated with long-term functional recovery after traumatic brain injury (TBI). We induced TBI with lateral fluid-percussion (LFP) injury in adult rats. Animals were followed-up for 9 months, during which we tested motor performance using a neuroscore test,(More)
Cerebrovascular changes following status epilepticus (SE) are not well understood, yet they may contribute to epileptogenesis. We studied hemodynamic changes in the cerebral cortex and amygdala by arterial spin labeling (ASL) and dynamic susceptibility contrast (DSC) MRI at 2 days and 14 days after pilocarpine-induced SE in rats. There were no cortical(More)
Hemodynamic and cerebrovascular factors are crucially involved in secondary damage after traumatic brain injury (TBI). With magnetic resonance imaging, this study aimed to quantify regional cerebral blood flow (CBF) by arterial spin labeling and cerebral blood volume by using an intravascular contrast agent, during 14 days after lateral fluid-percussion(More)
Cerebral blood flow (CBF) is disrupted after focal ischemia in rats. We examined long-term hemodynamic and cerebrovascular changes in the rat thalamus after focal cerebral ischemia. Cerebral blood flow quantified by arterial spin labeling magnetic resonance imaging was decreased in the ipsilateral and contralateral thalamus 2 days after cerebral ischemia.(More)
Status epilepticus or other brain-damaging insults launch a cascade of events that may lead to the development of epilepsy. MRI techniques available today, including T(2) - and T(1) -weighted imaging, functional MRI, manganese enhanced MRI (MEMRI), arterial spin labeling (ASL), diffusion tensor imaging (DTI), and phase imaging, can detect not only damage(More)
Folate plays a key role in DNA synthesis and methylation. Limited evidence suggests high intake may reduce risks of esophageal cancer overall; however, associations with esophageal cancer subtypes and Barrett's esophagus (BE), a precancerous lesion, remain unexplored. We evaluated the relation between intake of folate, B vitamins, and methyl-group donors(More)
Library is a lively and practical guide to running a school library. It is ideal for both teachers and others who are not trained librarians and places special emphasis on setting up a library with limited resources. The book gives simple step-by-step explanations and covers all aspects of setting up and running a library, including: • choosing a room and(More)
This paper describes the case of the National Assembly of Wales and the relevance of information and communications technology (ICT) to supporting its internal and external democratic processes. We review a number of tele-democracy initiatives from around the world and develop a case study of tele-democracy as it impacts upon a recent attempt to introduce a(More)
Magnetic resonance imaging of the hemodynamic and cerebrovascular sequelae of traumatic brain injury, ischemic stroke, and status epilepticus in rats To be presented by permission of the iv v Hayward, Nick. Magnetic resonance imaging of the hemodynamic and cerebrovascular sequelae of traumatic brain injury, ischemic stroke, and status epilepticus in rats.(More)
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