Nick Franks

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Classical anesthetics of the gamma-aminobutyric acid type A receptor (GABA(A))-enhancing class (e.g., pentobarbital, chloral hydrate, muscimol, and ethanol) produce analgesia and unconsciousness (sedation). Dissociative anesthetics that antagonize the N-methyl-D-aspartate (NMDA) receptor (e.g., ketamine, MK-801, dextromethorphan, and phencyclidine) produce(More)
Dexmedetomidine, the D-enantiomer of medetomidine, is among the most potent sedative drugs known. It is also one of the best understood in terms of its molecular and cellular mechanisms. Its sedative (and probably its neuroprotective) effects are mediated by subtype A of the α 2 adrenergic receptor, a G-protein-coupled receptor. Acting as an agonist at this(More)
The search for neural correlates of consciousness (NCC)-specific systems in the brain that correlate directly with states of conscious experience-has become an active area of research in recent years. Methods such as single-cell recording in monkeys and brain imaging and electrophysiology in humans, applied to such phenomena as blindsight, implicit/explicit(More)
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