Nick Curzen

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BACKGROUND The optimal management of patients found to have multivessel disease while undergoing primary percutaneous coronary intervention (P-PCI) for ST-segment elevation myocardial infarction is uncertain. OBJECTIVES CvLPRIT (Complete versus Lesion-only Primary PCI trial) is a U.K. open-label randomized study comparing complete revascularization at(More)
This paper introduces a low-complexity algorithm for the extraction of the fiducial points from the Electrocardiogram (ECG). The application area we consider is that of remote cardiovascular monitoring, where continuous sensing and processing takes place in low-power, computationally constrained devices, thus the power consumption and complexity of the(More)
  • Pamela S. Douglas, Gianluca Pontone, Mark A. Hlatky, Manesh R. Patel, Bjarne L. Norgaard, Robert A. Byrne +117 others
  • 2015
Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFR CT : outcome and resource impacts study Aims In symptomatic patients with suspected coronary artery disease (CAD), computed tomographic(More)
AIM We assessed the management and outcomes of non-ST segment elevation myocardial infarction (NSTEMI) patients randomly assigned to fractional flow reserve (FFR)-guided management or angiography-guided standard care. METHODS AND RESULTS We conducted a prospective, multicentre, parallel group, 1 : 1 randomized, controlled trial in 350 NSTEMI patients with(More)
In percutaneous coronary intervention (PCI), stent malapposition is a common complication often leading to stent thrombosis (ST). More recently, it has also been associated with longitudinal stent deformation (LSD) normally occurring through contact of a post balloon catheter tip and the protruding malapposed stent struts. The aim of this study was to(More)
In this paper, we address the problem of detecting the presence of a myocardial scar from the standard electrocardiogram (ECG)/vectorcardiogram (VCG) recordings, giving effort to develop a screening system for the early detection of the scar in the point-of-care. Based on the pathophysiological implications of scarred myocardium, which results in disordered(More)
Antiplatelet therapy with clopidogrel has been shown to reduce major adverse cardiac events in acute coronary syndromes and after percutaneous interventions. This effect is not only due to its anti-platelet effect but also possibly due to an anti-inflammatory effect. The effect of clopidogrel cessation after one year of therapy on markers of inflammation(More)
BACKGROUND Third-generation P2Y12 antagonists (prasugrel and ticagrelor) are recommended in guidelines on ST-segment elevation myocardial infarction. Mechanisms translating their more potent antiplatelet activity into improved clinical outcomes versus the second-generation P2Y12 antagonist clopidogrel are unclear. The aim of this post hoc analysis of the(More)
BACKGROUND FFR is routinely used to guide percutaneous coronary interventions (PCI). Visual assessment of the angiographic result after PCI has limited efficacy. Even when the angiographic result seems satisfactory FFR after a PCI might be useful for identifying patients with a suboptimal interventional result and higher risk for poor clinical outcome who(More)