Nick Clappers

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BACKGROUND Inadequate platelet inhibition despite aspirin and clopidogrel therapy during and after a percutaneous coronary intervention is associated with an impaired clinical outcome. Cangrelor, a direct and reversible P2Y(12) inhibitor that is currently in development, has the potential to achieve higher levels of inhibition of ADP-induced platelet(More)
Aspirin prevents thrombotic events by inhibiting platelet cyclooxygenase-1 (COX-1), thus reducing thromboxane A2 formation and platelet aggregation. The C50T polymorphism of COX-1 is associated with an impaired inhibition of both thromboxane production and in-vitro platelet aggregation by aspirin. We studied whether this polymorphism is also associated with(More)
The 28th Congress of the European Society of Cardiology this year was organized together with the World Heart Federation and was presented as the World Congress of Cardiology. During the congress, held in Barcelona in September 2006, the results of 11 new studies were presented in two Hotline sessions. One of these, the PEP-CHF study has already been(More)
BACKGROUND Over the past decade, radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) has evolved into a frequently performed procedure. The aim of this study was to monitor changes in patient characteristics, procedural characteristics, outcomes and complications over the past 10 years. METHODS All consecutive patients who underwent(More)
BACKGROUND The aminothiols homocysteine and, to a lesser extent, cysteine have been associated with adverse cardiovascular outcome, whereas glutathione, as an antioxidant, may protect against atherosclerosis and thrombosis. Potentially, the combined assessment of these aminothiols may provide a more accurate association with future cardiovascular outcome.(More)
Aims Adenosine testing can reveal dormant pulmonary vein (PV) conduction after PV antrum isolation (PVAI). However, the optimal timing for adenosine administration is unknown. We hypothesized that adenosine testing immediately after PVAI reliably reveals PV reconnection and thereby eliminates the need for an observation period. Methods and results Fifty(More)
Correspondence to: Professor F W A Verheugt, University Medical Center St Radboud, Heartcenter, 540 Cardiology, PO Box 9101, Nijmegen, The Netherlands 6500 HB; f.verheugt@cardio. umcn.nl _________________________ T hrombotic occlusion of an epicardial coronary artery has been implicated as a potential mechanism involved in acute myocardial infarction since(More)
Elevated total plasma homocysteine is an established risk factor for cardiovascular disease. Experimental evidence suggests that non-protein-bound free homocysteine is particularly hazardous to the vascular endothelium. This study evaluates the predictive role of free plasma homocysteine levels on cardiovascular endpoints in patients with acute coronary(More)