Nicholas Warr

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The putative transcription factor ZIC2 is associated with a defect of forebrain development, known as Holoprosencephaly (HPE), in humans and mouse, yet the mechanism by which aberrant ZIC2 function causes classical HPE is unexplained. The zinc finger domain of all mammalian Zic genes is highly homologous with that of the Gli genes, which are transcriptional(More)
Investigations of humans with disorders of sex development (DSDs) resulted in the discovery of many of the now-known mammalian sex-determining genes, including SRY, RSPO1, SOX9, NR5A1, WT1, NR0B1, and WNT4. Here, the locus for an autosomal sex-determining gene was mapped via linkage analysis in two families with 46,XY DSD to the long arm of chromosome 5(More)
The Schizosaccharomyces pombe homologue of Mre11, Rad32, is required for repair of UV- and ionising radiation-induced DNA damage and meiotic recombination. In this study we have investigated the role of Rad32 and other DNA damage response proteins in non-homologous end joining (NHEJ) and telomere length maintenance in S.pombe. We show that NHEJ in S.pombe(More)
The ZIC transcription factors are key mediators of embryonic development and ZIC3 is the gene most commonly associated with situs defects (heterotaxy) in humans. Half of patient ZIC3 mutations introduce a premature termination codon (PTC). In vivo, PTC-containing transcripts might be targeted for nonsense-mediated decay (NMD). NMD efficiency is known to(More)
P. Boutachkov,1,* M. Górska,1 H. Grawe,1 A. Blazhev,2 N. Braun,2 T. S. Brock,3 Z. Liu,4 B. S. Nara Singh,3 R. Wadsworth,3 S. Pietri,1 C. Domingo-Pardo,1 I. Kojouharov,1 L. Cáceres,1 T. Engert,1 F. Farinon,1 J. Gerl,1 N. Goel,1 J. Grbosz,5 R. Hoischen,6 N. Kurz,1 C. Nociforo,1 A. Prochazka,1 H. Schaffner,1 S. J. Steer,7 H. Weick,1 H.-J. Wollersheim,1 T.(More)
D. D. DiJulio,1,* J. Cederkall,1 C. Fahlander,1 A. Ekström,2 M. Hjorth-Jensen,2,3 M. Albers,4,† V. Bildstein,5,‡ A. Blazhev,4 I. Darby,6 T. Davinson,7 H. De Witte,6 J. Diriken,6,8 Ch. Fransen,4 K. Geibel,4 R. Gernhäuser,5 A. Görgen,9 H. Hess,4 J. Iwanicki,10 R. Lutter,11 P. Reiter,4 M. Scheck,12,§ M. Seidlitz,4 S. Siem,9 J. Taprogge,4 G. M. Tveten,9 J. Van(More)
J. Diriken a,b,∗, N. Patronis a,c, A.N. Andreyev a,d,e, S. Antalic f, V. Bildstein g, A. Blazhev h, I.G. Darby a, H. De Witte a, J. Eberth h, J. Elseviers a, V.N. Fedosseev i, F. Flavigny a, Ch. Fransen h, G. Georgiev j, R. Gernhauser g, H. Hess h, M. Huyse a, J. Jolie h, Th. Kröll g, R. Krücken g, R. Lutter k, B.A. Marsh i, T. Mertzimekis l, D. Muecher g,(More)
N. Bree, K. Wrzosek-Lipska, 2, ∗ A. Petts, A. Andreyev, 4 B. Bastin, 5 M. Bender, 7 A. Blazhev, B. Bruyneel, P. A. Butler, J. Butterworth, M. P. Carpenter, J. Cederkäll, 11 E. Clément, 11 T. E. Cocolios, 11, 12 A. Deacon, J. Diriken, 13 A. Ekström, C. Fitzpatrick, L. M. Fraile, 14 Ch. Fransen, S. J. Freeman, L. P. Gaffney, 3 J. E. Garćıa-Ramos, K. Geibel,(More)
M. Seidlitz,1 P. Reiter,1 R. Altenkirch,1 B. Bastin,2 C. Bauer,3 A. Blazhev,1 N. Bree,2 B. Bruyneel,1 P. A. Butler,4 J. Cederkäll,5 T. Davinson,6 H. De Witte,2 D. D. DiJulio,7 J. Diriken,2 L. P. Gaffney,4 K. Geibel,1 G. Georgiev,8 R. Gernhäuser,9 M. Huyse,2 N. Kesteloot,2 T. Kröll,3,9 R. Krücken,9,10 R. Lutter,11 J. Pakarinen,12 F. Radeck,1 M. Scheck,13,14(More)
The (n,n'γ) reaction has been used at the University of Kentucky accelerator facility to examine the detailed structure of a number of nuclei. The advantages of this method are reviewed, and recent developments are described. Examples of unique nuclear structure studies that have been carried out with this method are presented.