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Rap1 GTPases: an emerging role in the cardiovasculature.
The Ras related GTPase Rap has been implicated in multiple cellular functions. A vital role for Rap GTPase in the cardiovasculature is emerging from recent studies. These small monomeric G proteinsExpand
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Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.
Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. This activation leads to effector proteinExpand
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Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2.
The second messenger cyclic AMP (cAMP) plays a vital role in vascular physiology, including vasodilation of large blood vessels. We recently demonstrated cAMP activation of Epac-Rap1A andExpand
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Considerations and Strategies for Assessing: Simulation-Based Training in Interprofessional Education
Interprofessional education (IPE) often relies on simulation-based training to advance the education and performance of a multi-disciplinary team. As such, assessment and evaluation of theseExpand
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Electrophysiological abnormalities in mice with genetic ablation of Rap1a GTPase