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Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity
- Inês Pinheiro, R. Margueron, +11 authors T. Jenuwein
- Biology, Medicine
- Cell
- 31 August 2012
Heterochromatin serves important functions, protecting genome integrity and stabilizing gene expression programs. Although the Suv39h methyltransferases (KMTs) are known to ensure pericentric H3K9me3… Expand
A transcription factor–based mechanism for mouse heterochromatin formation
- Aydan Bulut-Karslioglu, V. Perrera, +12 authors T. Jenuwein
- Biology, Medicine
- Nature Structural &Molecular Biology
- 1 October 2012
Heterochromatin is important for genome integrity and stabilization of gene-expression programs. We have identified the transcription factors Pax3 and Pax9 as redundant regulators of mouse… Expand
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.
- Chunyu Jin, J. Li, +16 authors J. Han
- Biology, Medicine
- Cell metabolism
- 3 August 2011
Epigenetic modifications are thought to be important for gene expression changes during development and aging. However, besides the Sir2 histone deacetylase in somatic tissues and H3K4 trimethylation… Expand
Mammalian Su(var) genes in chromatin control.
- B. Fodor, Nicholas Shukeir, G. Reuter, T. Jenuwein
- Biology, Medicine
- Annual review of cell and developmental biology
- 6 October 2010
Genetic screens in Drosophila have been instrumental in distinguishing approximately 390 loci involved in position effect variegation and heterochromatin stabilization. Most of the identified genes… Expand
Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation
- Oscar Velazquez Camacho, C. Galán, +10 authors T. Jenuwein
- Chemistry, Medicine
- eLife
- 1 August 2017
The Suv39h1 and Suv39h2 histone lysine methyltransferases are hallmark enzymes at mammalian heterochromatin. We show here that the mouse Suv39h2 enzyme differs from Suv39h1 by containing an… Expand
H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction
- Sean E Healton, H. Pinto, +9 authors A. Skoultchi
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 8 June 2020
Significance Eukaryotic genomes harbor a vast number of “selfish” DNA elements, including transposable elements and repetitive sequences. They constitute nearly 50% of the human genome and need to be… Expand
A transcription factor–based mechanism for mouse heterochromatin formation
- Aydan Bulut-Karslioglu, V. Perrera, +12 authors T. Jenuwein
- Nature Structural &Molecular Biology
- 2013