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Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity

• Inês Pinheiro, Raphaël Margueron, +11 authors Thomas Jenuwein
• Cell
• 2012

Heterochromatin serves important functions, protecting genome integrity and stabilizing gene expression programs. Although the Suv39h methyltransferases (KMTs) are known to ensure pericentric H3K9me3… (More)

Mammalian Su(var) genes in chromatin control.

• Barna D Fodor, Nicholas Shukeir, G. Regel. M. Reuter, Thomas Jenuwein
• Annual review of cell and developmental biology
• 2010

Genetic screens in Drosophila have been instrumental in distinguishing approximately 390 loci involved in position effect variegation and heterochromatin stabilization. Most of the identified genes… (More)

A transcription factor–based mechanism for mouse heterochromatin formation

• Aydan Bulut-Karslioglu, Valentina Perrera, +12 authors Thomas Jenuwein
• Nature Structural &Molecular Biology
• 2013

Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.

• Chunyu Jin, Jing Li, +16 authors Jing-Dong Jackie Han
• Cell metabolism
• 2011

Epigenetic modifications are thought to be important for gene expression changes during development and aging. However, besides the Sir2 histone deacetylase in somatic tissues and H3K4 trimethylation… (More)

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation

• Oscar Velazquez Camacho, Carmen Galán, +10 authors Thomas Jenuwein
• eLife
• 2017

The Suv39h1 and Suv39h2 histone lysine methyltransferases are hallmark enzymes at mammalian heterochromatin. We show here that the mouse Suv39h2 enzyme differs from Suv39h1 by containing an… (More)

A transcription factor–based mechanism for mouse heterochromatin formation

• Aydan Bulut-Karslioglu, Valentina Perrera, +12 authors Thomas Jenuwein
• Nature Structural &Molecular Biology
• 2012

Heterochromatin is important for genome integrity and stabilization of gene-expression programs. We have identified the transcription factors Pax3 and Pax9 as redundant regulators of mouse… (More)

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