Nicholas Parziale

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OBJECTIVE To determine the safety and tolerability of mexiletine in a phase II double-blind randomized controlled trial of sporadic amyotrophic lateral sclerosis (SALS). METHODS Sixty participants with SALS from 10 centers were randomized 1:1:1 to placebo, mexiletine 300 mg/d, or mexiletine 900 mg/d and followed for 12 weeks. The primary endpoints were(More)
We report a case of dermatomyositis associated with rheumatoid arthritis, Hashimoto thyroiditis, and diabetes mellitus responsive only to combination of rituximab with mycophenolate. A 42-year-old woman presented with proximal muscle weakness, myalgias, fever, night sweats, and shortness of breath. Creatinine kinase was 8155 IU/L, and muscle biopsy was(More)
Measurement of the phenomena associated with hypervelocity boundary layer transition requires the development of high-speed detection techniques. Two reasons for the current search for a reliable non-intrusive optical technique include: 1) high-enthalpy facilities suffer from a harsh environment in the test section after the test time, 2) optical(More)
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