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- Publications
- Influence
Hydrogen peroxide is the major oxidant product of xanthine oxidase.
- E. Kelley, N. Khoo, Nicholas J. Hundley, U. Z. Malik, B. Freeman, M. Tarpey
- Chemistry, Medicine
- Free radical biology & medicine
- 15 February 2010
Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) in inflammatory disease. Focus, however, has centered almost exclusively on XO-derived superoxide (O(2)(*-)), whereas… Expand
Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production.
- U. Z. Malik, Nicholas J. Hundley, +4 authors E. Kelley
- Chemistry, Medicine
- Free radical biology & medicine
- 1 July 2011
Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) that contribute to vascular inflammation. Binding of XO to vascular endothelial cell glycosaminoglycans (GAGs) results in… Expand
Nitro-oleic Acid, a Novel and Irreversible Inhibitor of Xanthine Oxidoreductase*
- E. Kelley, C. Batthyány, +7 authors M. Tarpey
- Chemistry, Medicine
- Journal of Biological Chemistry
- 26 December 2008
Xanthine oxidoreductase (XOR) generates proinflammatory oxidants and secondary nitrating species, with inhibition of XOR proving beneficial in a variety of disorders. Electrophilic nitrated fatty… Expand
Structure Elucidation of Bioactive Compounds Isolated from Endophytes of Alstonia scholaris and Acmena graveolens
- Nicholas J. Hundley
- Biology
- 2005
STRUCTURE ELUCIDATION OF BIOACTIVE COMPOUNDS ISOLATED FROM ENDOPHYTES OF ALSTONIA SCHOLARIS AND ACMENA GRAVEOLENS Nicholas J. Hundley Department of Chemistry and Biochemistry Master of Science… Expand
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Binding of XOR to cellular glycosaminoglycans (GAGs) facilitates nitrite reductase activity under oxygenated conditions
- Nicholas J. Hundley, Christof J. Schoenborn, N. Cantu-Medéllin, J. Wang, M. Tarpey, E. Kelley
- Chemistry
- 15 July 2012
Under anoxic conditions, XOR catalyzes the one e− reduction of nitrite ( NO 2 - ) to NO at the Mo-cofactor. However, the conditions that favor e− transfer to NO 2 - at the Mo-cofactor over e−… Expand
Obesity-Induced Oxidative Stress: An Immunospin Trapping Study
- N. Khoo, N. Cantu-Medéllin, A. Fleming, Nicholas J. Hundley, B. Freeman, E. Kelley
- Chemistry
- 1 November 2011