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Hydrogen peroxide is the major oxidant product of xanthine oxidase.
Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) in inflammatory disease. Focus, however, has centered almost exclusively on XO-derived superoxide (O(2)(*-)), whereasExpand
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Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production.
Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) that contribute to vascular inflammation. Binding of XO to vascular endothelial cell glycosaminoglycans (GAGs) results inExpand
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Nitro-oleic Acid, a Novel and Irreversible Inhibitor of Xanthine Oxidoreductase*
Xanthine oxidoreductase (XOR) generates proinflammatory oxidants and secondary nitrating species, with inhibition of XOR proving beneficial in a variety of disorders. Electrophilic nitrated fattyExpand
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Structure Elucidation of Bioactive Compounds Isolated from Endophytes of Alstonia scholaris and Acmena graveolens
STRUCTURE ELUCIDATION OF BIOACTIVE COMPOUNDS ISOLATED FROM ENDOPHYTES OF ALSTONIA SCHOLARIS AND ACMENA GRAVEOLENS Nicholas J. Hundley Department of Chemistry and Biochemistry Master of ScienceExpand
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Binding of XOR to cellular glycosaminoglycans (GAGs) facilitates nitrite reductase activity under oxygenated conditions
Under anoxic conditions, XOR catalyzes the one e− reduction of nitrite ( NO 2 - ) to NO at the Mo-cofactor. However, the conditions that favor e− transfer to NO 2 - at the Mo-cofactor over e−Expand