Nicholas J. Patterson

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Schizophrenia is a common, multigenic psychiatric disorder. Linkage studies, including a recent meta-analysis of genome scans, have repeatedly implicated chromosome 8p12-p23.1 in schizophrenia susceptibility. More recently, significant association with a candidate gene on 8p12, neuregulin 1 (NRG1), has been reported in several European and Chinese samples.(More)
An interesting class of l inear error-correcting codes has been found by Goppa [3], [4]. This paper presents algebraic decoding algorithms for the Goppa codes. These algorithms are only a little more complex than Berlekamp’s well-known algorithm for BCH codes and, in fact, make essential use of his procedure. Hence the cost of decoding a Goppa code is(More)
Let X = X(m, y) be the set of skew-symmetric matrices of degree m (with zero diagonal) over GF(q). Suppose Y is a subset of X and that for every 24 , YZ E K yl yz is nonsingular (so m is even). The top rows of elements of Y are all distinct so that j Y j < q”-l. Kerdock [l] and Delsarte and Goethals [2] showed that in characteristic 2, this bound could(More)
The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in(More)
Flagellin potently induces inflammatory responses in mammalian cells by activating Toll-like receptor (TLR) 5. Recently, we were able to show that stimulation of bovine TLR5 resulted in neither NFκB signalling nor CXCL8 production. Like other TLRs, TLR5 recruits signalling molecules to its intracellular TIR domain, leading to inflammatory responses.(More)
Staphylococcus aureus, sequence type (ST) 398, is an emerging pathogen and the leading cause of livestock-associated methicillin-resistant S. aureus infections in Europe and North America. This strain is characterized by high promiscuity in terms of host-species and also lacks several traditional S. aureus virulence factors. This does not, however, explain(More)
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