Nicholas J Naftalin

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Strips of myometrium were obtained at operation from eight nonpregnant and ten pregnant patients. The tissues were immediately suspended in a muscle bath and induced to contract isometrically with K2SO4 in the presence and absence of halothane (0.5 to 2.0 vol per cent). The anesthetic produced significant dose-related depression of developed tension and(More)
The results of laser and cryosurgical treatment in 106 patients with histologically proven carcinoma in situ of the uterine cervix (CIN III) are presented. Seventy-one patients were treated with the laser and in 63 of these further follow-up with colposcopy and cytology failed to show any abnormality. This represents an initial success rate of 89%. In 8(More)
BACKGROUND Hysterectomy is the commonest elective major gynecological operation and the laparoscopic approach is increasingly an option. We evaluated the influence of the learning curve on the duration of surgery and also the peri-operative complications. METHODS A retrospective study of the case records of patients who had laparoscopically assisted(More)
The effects of halothane on isometirc contractions of isolated pregnant uterine muscle strips were evaluated in tissue obtained from 13 midpregnant rats. Peak developed tension was depressed in a dose-related manner at halothane concentrations above 0.8 vol per cent, but was not affected at lower halothane concentrations. Time to peak tension was reduced(More)
BACKGROUND "Referral" characterises a significant area of interaction between primary and secondary care. Despite advantages, it can be inflexible, and may lead to duplication. OBJECTIVE To examine the outcomes of an integrated model that lends weight to general practitioner (GP)-led evidence based care. DESIGN A prospective, non-random comparison of(More)
Isolated strips of mid-pregnant and postpartum rat myometrium were rendered functionally Ca2+-free by exposure to a Ca2+-free modified Krebs-bicarbonate solution containing 1 mM EGTA. The muscle strips were then exposed to 2.25 mM Ca2+ for periods of 15 to 600 seconds for the mid-pregnant tissues and one 120-second period for the postpartum tissues. At the(More)
OBJECTIVE A quantitative and qualitative evaluation of the views of patients attending two types of clinics for menstrual disorders. METHODS Semi-structured qualitative interview and quantitative questionnaire. SETTING Five traditional general gynaecology clinics and a one-stop menstrual clinic, where investigations are performed and results given to(More)