Nicholas J. Long

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Positron emission tomography (PET) is a powerful and rapidly developing area of molecular imaging that is used to study and visualize human physiology by the detection of positron-emitting radiopharmaceuticals. Information about metabolism, receptor/enzyme function, and biochemical mechanisms in living tissue can be obtained directly from PET experiments.(More)
Magnetic Resonance Imaging is perhaps the most important and prominent technique in diagnostic clinical medicine and biomedical research. Its success and development as an imaging technique has been aided by the characteristics of contrast agents that enhance signal intensities and improve specificity. Gadolinium(iii) remains the dominant starting material(More)
Molecular or personalised medicine is the future of patient management and healthcare, and molecular imaging plays a key role towards this goal. However, amongst molecular imaging techniques, no single modality is perfect and sufficient to gain all the necessary information. For instance, optical fluorescence imaging is difficult to quantify--especially in(More)
Magnetic nanoparticles represent one of the most advanced developments in the application of nanotechnology to human health. To date, their clinical application has been restricted to the diagnosis of hepatic lesions and lymph node metastasis but functionalization of these materials with biomolecules as targeting motifs, and the inclusion of therapeutic(More)
Despite the contribution of changes in pancreatic β-cell mass to the development of all forms of diabetes mellitus, few robust approaches currently exist to monitor these changes prospectively in vivo. Although magnetic-resonance imaging (MRI) provides a potentially useful technique, targeting MRI-active probes to the β cell has proved challenging. Zinc(More)
MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity and the commonly administered contrast agents lack specificity. In this study, two sets of iron oxide nanoparticles (IONPs) were synthesized that were designed to selectively undergo copper-free click conjugation upon sensing of matrix metalloproteinase (MMP)(More)
Dramatic increases in the luminescent lifetime of the Er3+ ion in a molecular complex have been observed by chelating the rare-earth ion with a perfluorinated imidodiphosphinate sensitizing ligand, F-tpip. For solution, powder, and evaporated thin films of Er(F-tpip)3, the average lifetimes of the 1530 nm emission band range between 150 and 220 mus,(More)
Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(III) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.
The purpose of this study was to determine whether there is a linear relationship between the squat and a variety of hamstring resistance training exercises, and whether this relationship differs on the basis of sex. This study also sought to create prediction equations for the determination of hamstring exercise load based on the squat load. Repetition(More)
The effect of various cholinergic agents on human spermatozoa motility was studied. Both direct-acting (e.g., acetylcholine, pilocarpine) and indirect-acting (e.g., physostigmine) cholinergic agonists stimulated human spermatozoa motility. All the cholinergic antagonists (e.g., atropine, hyoscine, hexamethonium, d-tubocurarine, and succinylcholine)(More)