Nicholas J Connors

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Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. Although there is no true antidote to cocaine toxicity, current management strategies address the life-threatening systemic effects, namely hyperthermia, vasospasm, and severe hypertension. Clinicians rely on rapid cooling, benzodiazepines, and α-adrenergic(More)
CONTEXT On October 29, 2012, Hurricane Sandy made landfall and devastated New York's metropolitan area, causing widespread damage to homes and the utility infrastructure. Eight days later, snow and freezing temperatures from a nor'easter storm delayed utility restoration. OBJECTIVE To examine carbon monoxide (CO) exposures in the 2 weeks following(More)
Given the current epidemic of harmful consequences from prescription opioids and heroin in the USA including 28,647 deaths due to opioids in 2014, naloxone has received widespread attention for use in hospital, prehospital, and bystander settings [1–3]. While naloxone can be a highly effective reversal agent for opioid poisoning, there appears to be a(More)
Opioid abuse and opioid overdose deaths have increased significantly over the past decade. Naloxone is a potentially life-saving medication that can reverse opioid-induced respiratory depression, though precipitated opioid withdrawal can pose acute risks to the patient and medical personnel. The optimal naloxone dose is unclear and few studies address this(More)
Keywords Acetaminophen toxicity. N-acetylcysteine. Opioid overdose. Body packing. Metal-on-metal hip prostheses Bateman DN, Dear JW, Thanacoody HK, et al. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomized controlled trial. Lancet 2013. Epub ahead of print. Background: Currently accepted management(More)
Atropine is the mainstay of therapy in organophosphate (OP) toxicity, though research and consensus on dosing is lacking. In 2004, as reported by Eddleston et al. (J Toxicol Clin Toxicol 42(6):865-75, 2004), they noted variation in recommended regimens. We assessed revisions of original references, additional citations, and electronic sources to determine(More)