Nicholas J Busch

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Acute hepatic failure develops as a disease entity of rather diverse origin. With disease progression, toxic bilirubin levels may cause severe complications which include AV-nodal blockage, cardiac arrhythmia, impaired consciousness, generalized seizures, and status epilepticus. Treatment choices to prevent clinical deterioration comprise of costly and(More)
Acute hepatitis can be caused by the enterically spread hepatitis A and E viruses and the parenterally spread hepatitis B, C or D viruses. The clinical features of acute viral hepatitis are similar among the five viruses and include non-specific symptoms and icterus. In general, a specific therapy is not necessary, but patients with fulminant hepatitis may(More)
PURPOSE To evaluate the T1 effect of superparamagnetic iron oxide (SPIO) in MR imaging of focal hepatic lesions. METHODS 21 patients with 34 liver lesions (18 benign) were examined before and immediately after infusion of SPIO particles (Endorem) with a T1-weighted GRE- and SE sequence and a double echo SE sequence at 1.5T. Changes of lesion signal(More)
HISTORY AND ADMISSION FINDINGS A 45-year-old woman was refferred for diagnosis of an accidentally found symptomless space-occupying lesions in the central part of the right lung. She had undergone a hysterectomy 4 years before and reported smoking 15 cigarettes daily since the age of 17 years. Physical examination was normal. INVESTIGATIONS As primary(More)
BACKGROUND/AIMS The aim of this study was to examine the metabolism of isoursodeoxycholic acid (isoUDCA) in humans. METHODS IsoUDCA was synthesized of >99% purity and administered orally for 1 week, 3 x 250 mg/day, to six healthy male subjects. Bile acids were extracted from duodenal bile, serum, and 24-h urine samples collected before and at the end of(More)
CERM 3517 (mociprazine), a new antiemetic compound, was administered orally at 10 mg/kg twice a day for 4 days to six Beagle dogs in order to identify the major metabolite. Mass spectrometric comparison of this metabolite and a synthesized reference compound (CERM 4082) showed that both had identical structures. The metabolite originated from cleavage of(More)