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BACKGROUND Epidemiological studies of the health effects of air pollution have traditionally relied upon ground-monitoring stations to measure ambient concentrations. Satellite derived air pollution measures offer the advantage of providing global coverage. OBJECTIVE To undertake a global assessment of mortality associated with long-term exposure to fine(More)
Amitriptyline (AT) relieves some patients with postherpetic neuralgia (PHN). Many patients suffer side effects and better therapies are necessary. The aim of this study was to evaluate the efficacy of maprotiline (MT) (noradrenergic) compared to AT (mixed noradrenergic and serotonergic) in this disorder. Thirty-five patients entered a randomized,(More)
Caffeine can produce a mild hypertensive effect for a few hours after use. Some epidemiological data relate chronic coffee intake to an increased risk of cardiovascular disease. We explored the possibility that a regular intake of caffeine-containing beverages (tea, coffee, cola) might produce a chronic increase in blood pressure and increase the likelihood(More)
OBJECTIVES To predict exercise stage transitions over two consecutive 6-month periods using the theory of planned behaviour (TPB). It was hypothesized that different social cognitive constructs would predict different stage transitions. DESIGN Prospective and longitudinal in order to predict multiple stage transitions over time. Assessments were made at(More)
BACKGROUND The purpose of this study was to test the ability of the Transtheoretical Model (TTM) to predict exercise stage transition of individuals in a large, untreated-population-based, random sample of Canadian adults (18-65 years of age) over two consecutive time periods. METHODS Assessments of TTM's stage of exercise behavior change, self-efficacy,(More)
Chlorination disinfection by-products (CDBPs) are produced during the treatment of water with chlorine to remove bacterial contamination. CDBPs have been associated with an increased risk of bladder cancer. There is also some evidence that they may increase the risk of pancreatic cancer. We report results from a population-based case-control study of 486(More)
The evaluation of diagnostic tests attempts to obtain one or more statistical parameters which can indicate the intrinsic diagnostic utility of a test. Sensitivity, specificity and predictive value are not appropriate for this use. The likelihood ratio has been proposed as a useful measure when using a test to diagnose one of two disease states (e.g.(More)
OBJECTIVE To provide health care professionals with guidelines on the use of blood pressure self-measurement. METHODS Recommendations were devised after consideration of expert reviews and guidelines, personal files, international standards documents, personal communication with investigators and the results of a MEDLINE search (1966-94) using the term(More)
BACKGROUND The number of women who delay childbirth to their late 30s and beyond has increased significantly over the past several decades. Studies regarding the relation between older maternal age and the risk of stillbirth have yielded inconsistent conclusions. In this systematic review we explored whether older maternal age is associated with an(More)