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- Nicholas Hunzelmann, Ekkehard Genth, +44 authors Valerie Bartels
- Rheumatology
- 2008
OBJECTIVE
Systemic sclerosis (SSc) is a rare, heterogeneous disease, which affects different organs and therefore requires interdisciplinary diagnostic and therapeutic management. To improve the… (More)
- Cord H Sunderkötter, Ilka Herrgott, +12 authors Gabriele Riemekasten
- The British journal of dermatology
- 2009
BACKGROUND
Digital ulcers (DU) are a major complication in the course of systemic sclerosis (SSc). In recent years, efficacious, but expensive therapies (e.g. iloprost, sildenafil, bosentan) have… (More)
- Leif Gunnar Hanitsch, Gerd R. Burmester, +11 authors Gabriele Riemekasten
- Rheumatology
- 2008
OBJECTIVES
In SSc, diagnosis and classification is based mainly on skin sclerosis. Herein, we investigated in a large multicentre cohort, to what extent skin sclerosis reflects organ involvement and… (More)
- Cord H Sunderkötter, Alexandra Kuhn, Nicholas Hunzelmann, Stefan Beissert
- Rheumatology
- 2006
In systemic sclerosis (SSc; scleroderma) fibrosis of the skin can lead to considerable morbidity. No significant improvement has been reported from studies investigating antifibrotic therapies so… (More)
- Felice Galluccio, Ulrich A. Walker, +12 authors Marco Matucci-Cerinic
- Rheumatology
- 2011
SSc is a multisystem disease characterized by an unpredictable course, high mortality and resistance to therapy. The complexity and severity of SSc is a growing burden on the health-care systems. As… (More)
- Jasper C. A. Broen, Lara Bossini-Castillo, +20 authors Timothy Rdj Radstake
- Journal of Translational Medicine
- 2011
T.R. was sponsored by the Dutch association of Research (NWO). J.M. was sponsored by grants SAF2009-1110, cts-4977 T.R. and J.M. were sponsored by the Orphan Disease program grant from the European… (More)
- Doreen Belz, Pia Moinzadeh, +22 authors Nicholas Hunzelmann
- 2017
Background Systemic sclerosis (SSc) is a chronic fibrosing autoimmune disease which leads to severe musculoskeletal dysfunction, disability and contractures. Little is known on the type and extent of… (More)
- Pia Moinzadeh, N Blank, +23 authors M Kreuter
- 2017
Background Lung involvement, i.e. interstitial lung disease (ILD) and pulmonary hypertension (PH), is common in patients with systemic sclerosis (SSc), significantly limiting quality of life and… (More)
- Jasper C. A. Broen, Phillipe Dieude, +20 authors Timothy Rdj Radstake
- The Journal of rheumatology
- 2012
OBJECTIVE
Polymorphisms in the genes encoding interleukin 4 (IL4), interleukin 13 (IL13), and their corresponding receptors have been associated with multiple immune-mediated diseases. Our aim was to… (More)