Nicholas Hunzelmann

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A rare polymorphism in Toll Like Receptor 2 is associated with systemic sclerosis phenotype and increases production of inflammatory mediators Jasper CA Broen, Lara Bossini-Castillo, Lenny van Bon, Madelon C Vonk, Hanneke Knaapen, Lorenzo Beretta, Blanca Rueda, Roger Hesselstrand, Ariane Herrick, Jane Worthington, Nicholas Hunzelmann, Christopher Denton,(More)
SSc is a multisystem disease characterized by an unpredictable course, high mortality and resistance to therapy. The complexity and severity of SSc is a growing burden on the health-care systems. As a result, researchers are seeking new therapeutic strategies for effectively managing these patients. Disease registries are used to support care management(More)
SSc is a multisystem disease characterized by an unpredictable course, high mortality and resistance to therapy. The complexity and severity of SSc is a growing burden on the health-care systems. As a result, researchers are seeking new therapeutic strategies for effectively managing these patients. Disease registries are used to support care management(More)
With strict binocular fixation, a slowly spinning sector disk of 7o diameter presented to the peripheral retina will rapidly appear to slow down and finally come to a stand-still. For a disk of alternating black and white sectors, the time needed to become fully adapted decreases with (a) increasing number of cycles (10, 15, 20); (b) decreasing speed of(More)
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