Nicholas Forestier

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BACKGROUND The application of iloprost, a stable prostacyclin analogue, by inhalation has been shown to improve hemodynamic variables in patients with primary pulmonary hypertension. However, repetitive inhalations are required due to its short-term effects. One potential approach to prolong and increase the vasorelaxant effects of aerosolized iloprost(More)
PURPOSE The purpose of this study was to investigate how an isometric exhaustion test affects the position sense at the ankle using an active matching task. METHODS Eight male subjects with a mean age 24.6 yr participated in the study. Subjects' ability to match the right ankle with the position of the left reference ankle position-determined using signed(More)
BACKGROUND The pulmonary circulation is an important site for the production and clearance of endothelin (ET)-1, a potent vasoactive and mitogenic peptide. In healthy individuals, 40% to 50% of circulating ET-1 is removed on each passage through the lungs resulting in an arteriovenous ratio of <1, whereas many patients with pulmonary arterial hypertension(More)
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