Nicholas E. Taylor

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Chemical mutagenesis has been the workhorse of traditional genetics, but it has not been possible to determine underlying rates or distributions of mutations from phenotypic screens. However, reverse-genetic screens can be used to provide an unbiased ascertainment of mutation statistics. Here we report a comprehensive analysis of approximately 1900 ethyl(More)
TILLING (Targeting Induced Local Lesions in Genomes) is a general reverse-genetic strategy that provides an allelic series of induced point mutations in genes of interest. High-throughput TILLING allows the rapid and low-cost discovery of induced point mutations in populations of chemically mutagenized individuals. As chemical mutagenesis is widely(More)
In many data sharing settings, such as within the biological and biomedical communities, global data consistency is not always attainable: different sites' data may be dirty, uncertain, or even controversial. Collaborators are willing to <i>share</i> their data, and in many cases they also want to selectively <i>import</i> data from others --- but must(More)
One of the most elusive goals of structured data management has been sharing among large, heterogeneous populations: while data integration [4, 10] and exchange [3] are gradually being adopted by corporations or small confederations, little progress has been made in integrating broader communities. Yet the need for largescale sharing of heterogeneous data(More)
PARSESNP is a tool for the display and analysis of polymorphisms in genes. Using a reference DNA sequence, an exon/intron position model and a list of polymorphisms, it determines the effects of these polymorphisms on the expressed gene product, as well as the changes in restriction enzyme recognition sites. It shows the locations and effects of the(More)
In many modern data management settings, data is queried from a central node or nodes, but is stored at remote sources. In such a setting it is common to perform "push- style" query processing, using multithreaded pipelined hash joins and bushy query plans to compute parts of the query in parallel; to avoid idling, the CPU can switch between them as delays(More)
Sharing structured data today requires standardizing upon a single schema, then mapping and cleaning all of the data. This results in a single queriable mediated data instance. However, for settings in which structured data is being collaboratively authored by a large community, e.g., in the sciences, there is often a lack of consensus about how it should(More)
The sciences, business confederations, and medicine urgently need infrastructure for sharing data and updates among collaborators' constantly changing, heterogeneous databases. The ORCHESTRA system addresses these needs by providing data transformation and exchange capabilities across DBMSs, combined with archived storage of all database versions. ORCHESTRA(More)
In recent years, the data management community has begun to consider situations in which data access is closely tied to network routing and distributed acquisition: examples include, sensor networks that execute queries about reachable nodes or contiguous regions, declarative networks that maintain information about shortest paths and reachable endpoints,(More)
The data management community has recently begun to consider declarative network routing and distributed acquisition: e.g., sensor networks that execute queries about contiguous regions, declarative networks that maintain shortest paths, and distributed and peer-to-peer stream systems that detect transitive relationships among data at the distributed(More)