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Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and immobilization. We show that activation of NF-kappaB, through muscle-specific transgenic expression of activated IkappaB kinase beta (MIKK), causes profound muscle wasting that resembles clinical cachexia. In contrast, no overt(More)
Muscle wasting is a major feature of the cachexia asso-One Joslin Place ciated with diverse pathologies such as cancer, bacte-Several cytokines have been implicated in the patho-8 Department of Pediatrics genesis of muscle wasting, most notably TNF-␣, a proin-9 Department of Physical Medicine flammatory cytokine that was originally called " cachec-and(More)
PURPOSE To determine if melanoma within the tumor microenvironment will result in immunosuppression within the draining lymph node as measured by down-regulation of T-cell receptor zeta (TCR zeta) expression. EXPERIMENTAL DESIGN Patients with clinical stage I to III melanoma undergoing wide local excision and sentinel lymph node biopsy or therapeutic(More)
Fistula formation between bowel and total hip arthroplasty or revision arthroplasty hardware is rare. We present a case of a 78-year-old woman with protrusio of left hip arthroplasty and acetabular reconstruction hardware that caused direct perforation of the sigmoid colon and fistula formation between the sigmoid colon and the left hip joint. The patient(More)
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