Nicholas B Taintor

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UNLABELLED A new generation of commercial animal PET cameras may accelerate drug development by streamlining preclinical testing in laboratory animals. However, little information on the feasibility of using these machines for quantitative PET in small animals is available. Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in(More)
UNLABELLED The use of mice with targeted gene deletions (knockouts [KOs]) provides an important tool to investigate the mechanisms underlying behavior, neuronal development, and the sequella of neuropsychiatric diseases. MRI has been used to image brain structural changes in KO mice but, to our knowledge, the feasibility of using PET to investigate brain(More)
Methylphenidate (MP) (Ritalin) is widely used for the treatment of attention deficit hyperactivity disorder (ADHD). It is a chiral drug, marketed as the racemic mixture of d- and l-threo enantiomers. Our previous studies (PET and microdialysis) in humans, baboons, and rats confirm the notion that pharmacological specificity of MP resides predominantly in(More)
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