Nicholas A. Floreani

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Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitness. At steady state, increased catabolism must be balanced by increasing mitochondrial biogenesis and protein(More)
2008. SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. 2013. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx(More)
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