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miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation.
Novel functions of miR-200c and GATA4 in regulating hESC renewal and differentiation are uncovered and these functions are related to self-renewal and differentiation. Expand
Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice.
- Y. Chiou, Nianhan Ma, S. Sang, C. Ho, Ying-Jan Wang, M. Pan
- Chemistry, Medicine
- Journal of agricultural and food chemistry
- 23 March 2012
Dietary feeding with AcEGCG markedly reduced colitis-driven colon cancer in mice and demonstrated for the first time the in vivo chemopreventive efficacy and molecular mechanisms of dietary AcEG CG against inflammatory bowel disease (IBD) and potentially colon cancer associated with colitis. Expand
Functional Module Connectivity Map (FMCM): A Framework for Searching Repurposed Drug Compounds for Systems Treatment of Cancer and an Application to Colorectal Adenocarcinoma
- Feng-Hsiang Chung, Yun-Ru Chiang, +5 authors Hoong-Chien Lee
- Biology, Medicine
- PloS one
- 27 January 2014
FMCM can be usefully applied to repurposed drug discovery for systems treatment of other types of cancer and other complex diseases, and is found to have higher robustness, accuracy, specificity, and reproducibility in identifying known anti-cancer agents. Expand
miR-596 Modulates Melanoma Growth by Regulating Cell Survival and Death.
- Szu-Mam Liu, Chen-huan Lin, +4 authors Nianhan Ma
- Biology, Medicine
- The Journal of investigative dermatology
- 1 November 2017
It is shown that miR-596 overexpression effectively inhibited MAPK/ERK signaling, cell proliferation, migration, and invasion and increased the cell apoptosis of melanoma cells, and it was found that mi R-596 directly targets MEK1 and two apoptotic proteins, MCL1, and BCL2L1, in melanomas cells. Expand
MicroRNA regulation of DNA repair gene expression in 4-aminobiphenyl-treated HepG2 cells.
It is indicated that mi RNA-513a-5p and miRNA-630 could play a role in the suppression of DNA repair genes, and eventually lead to DNA damage. Expand
5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis
5-Demethyltangeretin (5-DTAN), an autohydrolysis product of tangeretin (TAN) found in citrus peel, exhibited more potent anti-proliferative activity in human cancer cells than TAN itself. In this… Expand
Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells
Results show that DLK functions to suppress self-renewal of mouse ES cells and is restrained by Akt phosphorylation. Expand
Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions
- Chueh-Lin Hsu, Feng-Hsiang Chung, +7 authors Hoong-Chien Lee
- Biology, Medicine
- Scientific reports
- 6 September 2016
Functional genomic studies of CSC are conducted based on fourteen PCA-screened high quality public CSC whole genome gene expression datasets and, as control, four high quality non-stem-like cancer cell and non-cancerous stem cell datasets from the Gene Expression Omnibus database. Expand
Novel expression and regulation of TIMP-1 in Epstein Barr virus-infected cells and its impact on cell survival.
It is demonstrated that the EBV-encoded immediate early lytic protein, Zta, upregulates mainly TIMP-1 expression by binding to the AP-1 site within the TIMp-1 promoter. Expand
microRNA expression pattern as an ancillary prognostic signature for radiotherapy
Two miRNA classifiers could be developed as a potential non-invasive ancillary tool for predicting patient response to radiotherapy. Expand