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Identification of a potent MAR element from the mouse genome and assessment of its activity in stable and transient transfections.
Matrix attachment regions are DNA sequences found throughout eukaryotic genomes that are believed to define boundaries interfacing heterochromatin and euchromatin domains, thereby acting asExpand
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Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells
Successful generation of high producing cell lines requires the generation of cell clones expressing the recombinant protein at high levels and the characterization of the clones' ability to maintainExpand
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Using matrix attachment regions to improve recombinant protein production.
Chinese hamster ovary (CHO) cells are the system of choice for the production of complex molecules, such as monoclonal antibodies. Despite significant progress in improving the yield from theseExpand
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Sustained transgene expression using MAR elements.
Matrix attachment regions (MARs) are DNA sequences that may be involved in anchoring DNA/chromatin to the nuclear matrix and they have been described in both mammalian and plant species. MARs possessExpand
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Molecular Characterization of a Human Matrix Attachment Region Epigenetic Regulator
Matrix attachment regions (MAR) generally act as epigenetic regulatory sequences that increase gene expression, and they were proposed to partition chromosomes into loop-forming domains. However,Expand
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MAR Elements and Transposons for Improved Transgene Integration and Expression
Reliable and long-term expression of transgenes remain significant challenges for gene therapy and biotechnology applications, especially when antibiotic selection procedures are not applicable. InExpand
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Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest
We developed a method for the fast sorting and selection of mammalian cells expressing and secreting a protein at high levels. This procedure relies on cell capture using an automated microfluidicExpand
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Cover Image, Volume 114, Number 8, August 2017
Cover Legend The cover image, by Xuan Droz et al., is based on the Article Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently expressExpand