Niall Keenan

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AIMS Troponin measurement is used in the assessment and risk stratification of patients presenting acutely with chest pain when the main cause of elevation is coronary artery disease. However, some patients have no coronary obstruction on angiography, leading to diagnostic uncertainty. We evaluated the incremental diagnostic value of cardiovascular magnetic(More)
PURPOSE To compare a multislab three-dimensional volume-selective fast spin-echo (FSE) magnetic resonance (MR) sequence with a routine two-dimensional FSE sequence for quantification of carotid wall volume. MATERIALS AND METHODS One hundred normal subjects (50 men, mean age 44.6 years) underwent carotid vessel wall MR using 2D and 3D techniques. Carotid(More)
Obesity is a major risk factor for cardiometabolic disease, but the effect of body composition on vascular aging and arterial stiffness remains uncertain. We investigated relationships among body composition, blood pressure, age, and aortic pulse wave velocity in healthy individuals. Pulse wave velocity in the thoracic aorta, an indicator of central(More)
BACKGROUND Cardiac phenotypes, such as left ventricular (LV) mass, demonstrate high heritability although most genes associated with these complex traits remain unidentified. Genome-wide association studies (GWAS) have relied on conventional 2D cardiovascular magnetic resonance (CMR) as the gold-standard for phenotyping. However this technique is(More)
This paper presents a novel approach to shape extraction and interpretation in 4-D cardiac magnetic resonance imaging data. Statistical modeling of spatiotemporal interlandmark relationships is performed to enable the decomposition of global shape constraints and subsequently of the image analysis tasks. The introduced descriptors furthermore provide(More)
BACKGROUND No previous study has looked for an association between aortic dilatation and the clinical sequelae of patent foramen ovale (PFO), although a possible relationship has been identified in case reports. AIM To compare aortic dimensions in patients with symptomatic PFO and healthy controls. METHODS Forty-seven patients were identified who(More)
Peritonitis is a major complication of peritoneal dialysis (PD). Coagulase-negative staphylococcus, Staphylococcus aureus , and Gram-negative bacteria cause the majority of these infections and usually are amenable to conventional antibiotic therapy, allowing continuation of PD. Mycobacterial and fungal peritonitis represent a more difficult clinical(More)
Cardiovascular magnetic resonance (CMR) is the reference standard for the assessment of ventricular dimensions, function, and mass in terms of accuracy and reproducibility. It has been thoroughly validated both ex vivo and against other imaging techniques. Measurements are highly accurate and no geometrical assumptions need to be made about the ventricle. A(More)
PURPOSE To evaluate semiautomated analysis software for measuring the total carotid arterial wall volume (TWV) as a measure of atheroma burden. MATERIALS AND METHODS Semiautomated-software and manual analyses of TWV measured by cardiovascular magnetic resonance (CMR) were compared in two phantom models, 10 subjects with no known carotid artery disease,(More)