Ni-Huiping Son

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BACKGROUND Diabetes mellitus and obesity, which confer an increased risk of sudden cardiac death, are associated with cardiomyocyte lipid accumulation and altered cardiac electric properties, manifested by prolongation of the QRS duration and QT interval. It is difficult to distinguish the contribution of cardiomyocyte lipid accumulation from the(More)
Aldose reductase (AR), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury. We investigated whether deleterious effects of AR are due to its actions specifically in cardiomyocytes. We created mice with cardiac specific expression of human(More)
CD36 deficiency impairs the small intestinal barrier and induces subclinical inflammation in mice. SUMMARY This study documents that CD36 is important for intestinal homeostasis. CD36 deletion associates in the gut with altered extracellular matrix, neutrophil infiltration, and defective epithelial barrier. Systemically, the deletion results in subclinical(More)
Background—Diabetes mellitus and obesity, which confer an increased risk of sudden cardiac death, are associated with cardiomyocyte lipid accumulation and altered cardiac electric properties, manifested by prolongation of the QRS duration and QT interval. It is difficult to distinguish the contribution of cardiomyocyte lipid accumulation from the(More)
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