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Biological rhythms are driven in mammals by a central circadian clock located in the suprachiasmatic nucleus (SCN). Light-induced phase shifting of this clock is correlated with phosphorylation of CREB at Ser133 in the SCN. Here, we characterize phosphorylation of CREB at Ser142 and describe its contribution to the entrainment of the clock. In the SCN,(More)
In most mammals, daily rhythms in physiology are driven by a circadian timing system composed of a master pacemaker in the suprachiasmatic nucleus (SCN) and peripheral oscillators in most body cells. The SCN clock, which is phase-entrained by light-dark cycles, is thought to synchronize subsidiary oscillators in peripheral tissues, mainly by driving cyclic(More)
We consider the problem of determining a pair of functions (u, f) satisfying the two-dimensional backward heat equation u t − ∆u = φ(t)f (x, y), t ∈ (0, T), (x, y) ∈ (0, 1) × (0, 1), u(x, y, T) = g(x, y) with a homogeneous Cauchy boundary condition, where φ and g are given approximately. The problem is severely ill-posed. Using an interpolation method and(More)
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