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Single-nucleotide polymorphisms in the tumor necrosis factor, alpha-induced protein 3 gene, which encodes the ubiquitin-modifying protein A20, are linked to susceptibility to multiple sclerosis (MS), a demyelinating autoimmune disease of the central nervous system (CNS). Since it is unresolved how A20 regulates MS pathogenesis, we examined its function in a(More)
Amyloid peptides are formed during inflammation and modify the function of immune cells. The present study explored the effect of amyloid beta-peptide (Abeta(1-42)) and islet amyloid polypeptide (IAPP) on bone marrow derived dendritic cells (DCs). DCs were treated with Abeta(1-42) or IAPP with subsequent assessment of ceramide formation, caspase 8 and 3(More)
BACKGROUND The development and current state of Vietnamese neurosurgery is presented, in order to highlight the difficulties faced by neurosurgeons in Vietnam and other developing countries. METHODS Information has been collected personally by the authors in Vietnam. RESULTS The conditions of neurosurgery endured by our neurosurgical colleagues in(More)
BACKGROUND Androgen signaling plays a critical role in the development of prostate cancer and its progression. However, androgen-independent prostate cancer cells emerge after hormone ablation therapy, resulting in significant clinical problems. We have previously demonstrated that the HOXB13 homeodomain protein functions as a prostate cancer cell growth(More)
Dendritic cells (DCs) are the most potent professional antigen-presenting cells for naive T cells to link innate and acquired immunity. Klotho, an anti-aging protein, participates in the regulation of Ca2+ dependent migration in DCs. Vitamin E (VitE) is an essential antioxidant to protect cells from damage and elicits its inhibitory effects on(More)
Based on 249 observations acupuncture analgesia has been studied in its clinical picture and its abilities in surgery. Clinically, whatever may be the acupuncture sites, the first appearance of analgesia is noticed on the hands, the feet, the vertex, the auricles of the ears. Then, from these areas the propagation of analgesia extends towards the trunk(More)
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