Ngoc-Anh T. Nguyen

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The utilization time for a parenteral prodrug solution with a bioavailable fraction of unity was defined as the time during which the total of the prodrug concentration and the drug concentration equals or exceeds 90% of the initial prodrug concentration. This utilization time was calculated as a function of pH, buffer, and temperature using the(More)
The utilization time (UT) for a solution of a prodrug that is rapidly and completely converted to drug in the blood may be longer than the time for 10% loss of the initial concentration. The UT for an intravenous prodrug solution is the period during which the total prodrug and drug concentration exceeds 90% of the initial concentration. The influence of(More)
A new method of electropalatographic (EPG) data reduction is proposed. It uses the so-called discrete cosine transform for representing an EPG pattern as a weighted sum of elementary 'pictures'. It is shown that several of these pictures can be considered as being articulatorily relevant. The respective contributions of these pictures to the spatial(More)
Mobile convergence is an emerging trend in the wireless communication industry. Modern multi-standard mobile phones are required to provide a variety of location independent services like voice, data, video, the Internet and multimedia content without compromising on their weight, volume and performance. Therefore, it is important to develop compact(More)
Cefuroxime axetil, an ester prodrug of cefuroxime, is comprised of a 50:50 mixture of diastereomers A and B. The first-order hydrolysis kinetics of cefuroxime axetil were investigated as a function of pH, temperature, buffers, and ionic strength. Chromatographically identified hydrolysis products were cefuroxime, Δ2-cefuroxime axetil, and α,β-sulfoxides.(More)
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