Nghia Q. Nguyen

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A first-principles task-based approach to the design of medical ultrasonic imaging systems for breast lesion discrimination is described. This study explores a new approximation to the ideal Bayesian observer strategy that allows for object heterogeneity. The new method, called iterative Wiener filtering, is implemented using echo data simulations and a(More)
Beamforming of received pulse-echo data generally involves the compression of signals from multiple channels within an aperture. This compression is irreversible, and therefore allows the possibility that information relevant for performing a diagnostic task is irretrievably lost. The purpose of this study was to evaluate information transfer in beamforming(More)
This paper describes a task-based, information-theoretic approach to the assessment of image quality in diagnostic sonography. We expand the Kullback-Leibler divergence metric J, which quantifies the diagnostic information contained within recorded radio-frequency echo signals, into a spatial-frequency integral comprised of two spectral components: one(More)
In this paper, we explore relationships between the performance of the ideal observer and information-based measures of class separability in the context of sonographic breast-lesion diagnosis. This investigation was motivated by a finding that, since the test statistic of the ideal observer in sonography is a quadratic function of the echo data, it is not(More)
— We have been developing the ideal observer formalism for sonography, which is based on the best-possible diagnostic performance. The ideal performance was compared to that of trained human observers to estimate the visual efficiency for discriminating lesion features. We find that humans are generally less than 10% efficient at accessing visual(More)
— We show that the minimum-variance (MV), Wiener-filtered (WF), and other beamformers can be derived as approximations to the ideal-observer's strategy for lesion feature discrimination. We analyze breast lesion discrimination performance for five beamformers. Four of the five include matching filtering of receive-channel signal before summation, because(More)
Virtually every area of ultrasonic imaging research requires accurate estimation of the spatiotemporal impulse response of the instrument, and yet accurate measurements are difficult to achieve. The impulse response can also be difficult to predict numerically for a specific device because small unknown perturbations in array properties can generate(More)
We are developing a first-principles task-based approach to the optimal design and evaluation of ultrasonic imaging systems. Examining five clinical features related to breast lesion diagnosis, we quantified information flow at several stages in the image formation process. We found that the diagnostic performance of a given system configuration will vary(More)
Transmitted pressure pulses in ultrasonic B-mode imaging systems are commonly characterized by their center frequency and bandwidth. Both parameters are associated with tradeoffs in spatial resolution and signal-to-noise in ultrasonic system design, with no general understanding of where they are optimal when applied to specific clinical exams. We use the(More)