Ngaihang Victor Chong

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Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of complement activation underlies AMD, parameters of complement activation in blood plasma were determined(More)
PURPOSE To determine architectural differences between classic and occult choroidal neovascularization (CNV) in vivo. DESIGN Prospective observational case series. METHODS Twenty-two patients with acute CNV underwent fluorescein angiography and optical coherence tomography (OCT), which were analyzed by separate blinded observers. RESULTS In 87.5% of(More)
PurposeTo evaluate the application of 488 and 514 nm fundus autofluorescence (FAF) and macular pigment optical density (MPOD) imaging in diabetic macular oedema (DMO) and to demonstrate the typical imaging features.Patients and MethodsA hundred and twenty-five eyes of 71 consecutive patients with diabetic retinopathy who underwent examination at a(More)
PURPOSE To investigate the feasibility and to identify sources of experimental variability of quantitative and qualitative fundus autofluorescence (AF) assessment in mice. METHODS Blue (488 nm) and near-infrared (790 nm) fundus AF imaging was performed in various mouse strains and disease models (129S2, C57Bl/6, Abca4(-/-), C3H-Pde6b(rd1/rd1), Rho(-/-),(More)
OBJECTIVES To determine the role of systemic complement activation in the pathogenesis of age-related macular degeneration and to examine whether serum C3a des Arg reflects systemic complement activation, independent of individual complement component levels. METHODS Plasma complement C3a des Arg levels and a single nucleotide polymorphism at position 402(More)
PURPOSE To compare the efficacy of intravitreal aflibercept and ranibizumab on the exudative activity of neovascular age-related macular degeneration (nAMD) using optical coherence tomography (OCT) and to correlate morphologic findings with visual acuity (VA) outcomes. DESIGN Post hoc analysis of the prospective VIEW trials. PARTICIPANTS Data of 1815(More)
Experienced physicians using the direct ophthalmoscope lack confidence and often fail to notice important abnormalities.1–3 Missed or delayed detection of ophthalmic signs can result in harm to patients: undetected disc swelling could lead to loss of vision from persistently raised intracranial pressure; an undiagnosed retinal artery occlusion could prevent(More)
PURPOSE To compare diabetic retinopathy (DR) severity grading between Optomap ultrawide field scanning laser ophthalmoscope (UWFSLO) 200° images and an Early Treatment Diabetic Retinopathy Study (ETDRS) seven-standard field view. METHODS Optomap UWFSLO images (total: 266) were retrospectively selected for evidence of DR from a database of eye clinic(More)
PURPOSE Dysregulation of the extracellular matrix (ECM) plays an important role in the pathogenesis of age-related macular degeneration (AMD). Elastin is a fibrous protein constituent of the ECM, degradation of which may be detected by the presence of serum elastin-derived peptides (S-EDPs) in circulation. This study was undertaken to estimate levels of(More)
I would like to make it clear from the very beginning that I am not against the use of Avastin in the National Health Service (NHS), but just not in neovascular age-related macular degeneration (AMD). I am also not saying that we should never use Avastin for neovascular AMD in the NHS, but just not now, in 2009. So what is missing and why not? Let me take(More)