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The present study investigated the effects of a functional deficit in insulin-like growth factor-I signaling via chronic intravenous administration of insulin-like growth factor-I (IGF-I) receptor antisense in the conscious spontaneously hypertensive rat cardiovascular system. Insulin-like growth factor-I receptor (IGF-IR) antisense, but not full mismatch(More)
Effective treatment for managing myocardial infarction (MI) remains an urgent, unmet clinical need. Formyl peptide receptors (FPR) regulate inflammation, a major contributing mechanism to cardiac injury following MI. Here we demonstrate that FPR1/FPR2-biased agonism may represent a novel therapeutic strategy for the treatment of MI. The small-molecule(More)
Aust t t t t t tra ra ra ra ra ra rali li li li li li lia a a a a a a & & Di Diab ab b b b t t et t etes es I I I Ins nsti ti ti ti t tu t tute te t t Abstract Background—Nitroxyl (HNO), a redox congener of nitric oxide (NOx), is a novel regulator
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