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Some of the most effective anti-mitotic microtubule-binding agents, such as paclitaxel (Taxus brevifolia) were originally discovered through robust National Cancer Institute botanical screenings. In this study, a high-through put microarray format was utilized to screen 897 aqueous extracts of commonly used natural products (0.00015-0.5 mg/mL) relative to(More)
We demonstrate an efficient algorithm for the optimum topology design of continuum structures using parallel computers. The homogenization method provides a rigorous method for determining the optimum topology of a structure subject to specified loads and boundary conditions. This paper describes our efforts to improve the computational efficiency of the(More)
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