Nevine Guirguis Nessim

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The effect of the broad spectrum anthelmintic drug flubendazole (methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamate, CAS 31430-15-6), a mebendazole derivative with a molecular weight of 313.29, on Schistosoma mansoni infection in mice was evaluated. Moreover, the relationship between the posttreatment worm burden, hepatic granuloma volume, and serum(More)
The possible additive or synergistic effects of both praziquantel (CAS 55268-74-1) and a new antischistosomal drug, Ro 15-5458 (10-(2-diethylamino)thyl)-9-acridanone(thiazolidin-2-yl-i dene)hydrazone, CAS 92928-47-7) were studied in two different strains of Schistosoma mansoni infected mice, namely CD susceptible and SO4 resistant strains. Assessment of(More)
This study was conducted to evaluate the efficacy of praziquantel (CAS 55268-74-1, EMBAY 8440, Biltricide) in different grades of Schistosoma mansoni infection. Moreover, the relationship between the post treatment worm burden, hepatic granuloma volume, and serum immunoglobin profile was also investigated. Four groups of Swiss albino mice infected with(More)
This study is a trial to demonstrate the effect of the broad spectrum anthelmintic drug flubendazole (methyl 5-(p-fluoro-benzoyl)-2-benzimidazolecarbamate, CAS 31430-15-6), a mebendazole derivative, together with praziquantel (CAS 55268-74-1, EMBAY 8440, Biltricide) in murine schistosomiasis mansoni. Moreover, the relationship between the posttreatment worm(More)
OBJECTIVES This study was a trial to demonstrate the prophylactic effect of diclofenac, a widely used anti-inflammatory drug (diclofenac potassium, CAS-15307-81-0, Ciba Geigy, 334.2) in experimental schistosomiasis mansoni. Two different dose regimens were used to explore the effects upon worm load, tissue egg load, and hepatic granuloma size. METHODS In(More)
In this study, the maximal excretion of Giardia lamblia cysts was three weeks post infection (p.i). Administration of ivermectin subcutaneously proved to be effective in treating hamsters infected for 2 and 3 weeks respectively. It was found that the dose of 300 microg/kg b.w. was much more efficient than 200 mg/kg b.w. The cure rate was 99.1% in the(More)
This work is a trial to evaluate the effect of the combination of the anthelmintic drug praziquantel (CAS 55268-74-1, PZQ, EMBAY 8440, Biltricide) with the antifibrotic agent beta-aminopropionitrile-monofumarate salt (BAPN, CAS 2079-89-2). It is also a trial to elucidate the repercussions of this drug combination upon worm and tissue egg loads and oogram(More)
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