Neven Makram Aziz

Learn More
In Rat-1 fibroblasts nonmitogenic doses of lysophosphatidic acid (LPA) stimulate a transient activation of mitogen-activated protein kinase (MAPK), whereas mitogenic doses elicit a sustained response. This sustained phase of MAPK activation regulates cell fate decisions such as proliferation or differentiation, presumably by inducing a program of gene(More)
alpha Melanocyte-stimulating hormone (alphaMSH) is a 13 amino acid peptide with potent anti-inflammatory effects. We created two DNA expression constructs (miniPOMC and pACTH1-17) that encode bioactive versions of the alphaMSH peptide, and tested these constructs for therapeutic effects in experimental autoimmune encephalomyelitis (EAE). Each construct(More)
Carbon monoxide (CO) has been found to be produced in every living cell in a biochemical reaction catalyzed by heme-oxygenase (HO) enzyme which degrades heme into biliverdin, CO, and iron. Endogenous CO is not a waste product, but acts as a chemical messenger mediating and modulating many intracellular biochemical reactions that regulate physiological(More)
Ras-activated signal transduction pathways are implicated in the control of cell proliferation, differentiation, apoptosis, and tumorigenesis, but the molecular mechanisms mediating these diverse functions have yet to be fully elucidated. Conditionally active forms of Raf, v-Src, and MEK1 were used to identify changes in gene expression that participate in(More)
UNLABELLED This study evaluates the effects produced by H2S donor; sodium hydrosulfide (NaHS), in a renal ischemia/reperfusion (IR) rat model and assesses the possible mediating role of nitric oxide (NO) in these H2S' effects. BACKGROUND For several centuries, hydrogen sulfide (H₂S) had been known to be a highly toxic agent. Recent studies, however,(More)
BACKGROUND Stress disturbs homeostasis and may induce various disorders. Immobilization stress (IS) induced due to reduced area provided for mobility results in the imbalance of oxidant and antioxidant status. Stress leads to male reproductive dysfunction in many species, including rodents and humans. Induction of heme oxygenase-1 (HO-1), the rate limiting(More)
OBJECTIVE Multiple stimulatory and inhibitory inputs regulate the hypothalamic-pituitary-adrenal axis (HPA). Although the results of the previous studies are contradictory, it has been indicated that the carbon monoxide (CO) may play a role in the HPA regulation. The aim of the present study was to investigate the effect of modified endogenous CO production(More)
OBJECTIVE This study was aimed to assess the effect of both the estrogen and growth hormone releasing peptide-6 (GHRP-6), on the cardiovascular and metabolic diseases in ovariectomized (OVX) rats. METHOD Four groups of adult female rats were used: sham operated, OVX, OVX plus estrogen supplemented, and OVX plus GHRP-6 supplemented. After 8 weeks, blood(More)