Neuza T. O. Fukumori

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UNLABELLED A rapid quantitative kinetic chromogenic test in an automated portable test system has been developed for in-process and end-product determination of bacterial endotoxins in water using the Limulus amebocyte lysate. The aim of this work was to validate the method for (18)F-FDG, (99m)Tc, and the lyophilized reagents methylene diphosphonic acid(More)
UNLABELLED The aim of this work was to develop a selective method for quantification of Sn(II) and Sn(IV) in dimercaptosuccinic acid (DMSA), ethylcysteinate dimer (ECD), methylenediphosphonic acid (MDP), and pyrophosphate radiopharmaceutical cold kits by differential pulse polarography. METHODS A dripping mercury electrode 150 polarographic/stripping(More)
Before the Limulus amebocyte lysate (LAL) test, the only available means of pirogenicity testing for parenteral drug products and medical devices was the United States Pharmacopoeia (USP) rabbit pyrogen test. Especially for radiopharmaceuticals, the LAL test is the elective way to determine bacterial endotoxin. The aim of this work is to define and validate(More)
In this work, molybdenum-99 loaded columns were challenged with Bacillus subtilis vegetative cells and Bacillus pumilus spores inside and outside the alumina column, and microbial recovery and radiation effect were assessed. Alumina was a barrier for the passage of microorganisms regardless the species, whilst spores were more retained than vegetative cells(More)
A sensitive, alternative method to atom absorption spectometry, fluorimetry or potentiometry for the evaluation of tin(II) ions (0.110mg) and total tin in radiopharmaceutical kits was investigated. Differential pulse polarography was chosen. The supporting electrolyte was H2SO4 3 mol L -1 and HCl 3 mol L -1 solution. The potential was swept from –250 to(More)
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