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We have used the rat formalin test to compare the anti-nociceptive properties of several voltage-activated Na(+) channel blockers. The antiarrhthymic mexiletine (37.5 and 50 mg/kg, i.p.) attenuated flinching behaviour in both first and second phases of the test compared with vehicle (P<0.05). The anti-convulsants lamotrigine (15 and 30 mg/kg, i.p.) and(More)
INTRODUCTION Broadway lies in a region of England that has been strongly affected by successive periods of periglacial conditions, located just below the southern extent of last glacial advances. Broadway contains evidence of relict periglacial features as well as more recent landslide activity. As part of a general study of mass movements in relict(More)
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