Nestor Hofmann

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Chromatin condensation is vital for the function of the spermatozoon as the motile carrier of the paternal genome. The degree of condensation can be shown with the aid of acidic aniline blue staining, which is able to discriminate between lysine-rich histones and arginine- and cysteine-rich protamines. Using this technique and employing the Düsseldorf(More)
Testicular biopsies from two patients with alcohol induced fertility disturbances and one patient with intact spermatogenesis were investigated with the help of histological and enzyme histochemical methods. Main alcohol induced changes include: 1. loss of typical arrangement of elongated spermatids in the form of a "bunch of grapes", dominance of(More)
On the basis of microscopical examination and further differentiation by special stain techniques, a new classification of defects of midpieces and tails of spermatozoa will be presented: First degree disorders i.e. abnormalities of the staining behaviour and minor structural defects, second degree disorders revealing breakes and coiling of spermatozoa(More)
The acrosome reaction of human spermatozoa with different morphological disturbances was evaluated after application of the triple staining method. After triple staining, spermatozoa which display only a small or an undetectable acrosomal region in Papanicolaou-stained semen smears, turn out to be unable to perform an acrosome reaction, whereas merely(More)
Pituitary tuberculomas are exceptionally rare. Even with no evidence of systemic tuberculosis, it is important to recognize these lesions in the differential diagnosis of the intrasuprasellar tumors because they are curable. At present, in developed countries the frequency of intracranial tuberculomas of nervous system tumors is around 0.5-4%, whereas in(More)