• Publications
  • Influence
Synthesis of 4H-chromene, coumarin, 12H-chromeno[2,3-d]pyrimidine derivatives and some of their antimicrobial and cytotoxicity activities.
Condensation of 3-N,N-diethylaminophenol (1) with α-cyanocinnamonitriles (2a-c) and ethyl α-cyanocinnamates (2d-f) provided compounds 3a-f and 4a-c. 12H-Chromeno[2,3-d]pyrimidine derivatives 6, 11-13Expand
  • 147
  • 2
Analgesic, anticonvulsant and anti-inflammatory activities of some synthesized benzodiazipine, triazolopyrimidine and bis-imide derivatives.
A series of diazipine, pyrimidine, fused triazolopyrimidine and imide derivatives were newly synthesized using 4-phenyl-but-3-en-2-one 1 as a starting material and compounds 2 and 9 areExpand
  • 69
  • 1
Synthesis, Analgesic, and Antiparkinsonian Profiles of Some Pyridine, Pyrazoline, and Thiopyrimidine Derivatives
Summary.A series of substituted pyridine, pyrazoline, and thiopyrimidine derivatives were synthesized from 3-acetylpyridine, which was prepared from nicotinic acid as a naturally starting material.Expand
  • 39
  • 1
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
Treatment of 3-cyanoacetyl indole 1 with the diazonium salts of 3-phenyl-5-aminopyrazole and 2-aminobenzimidazole afforded the corresponding hydrazones 4 and 5. 3-Cyanoacetyl indole reacted withExpand
  • 174
Synthesis, Reactions, and Anti-inflammatory Activity of Heterocyclic Systems Fused to a Thiophene Moiety Using Citrazinic Acid As Synthon
Summary.A series of pyridines, pyrimidinones, and oxazinones were synthesized as anti-inflammatory agents using citrazinic acid (2,6-dihydroxyisonicotinic acid) as a starting material. AcryloylExpand
  • 75
Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential naprosyn® analogs as COX-1 and/or COX-2 inhibitors.
Inflammation is a fundamental physiological process that is essential for survival of human being but at the same time is one of the major causes of human morbidity and mortality. In the past decade,Expand
  • 9
Anti‐Inflammatory and Analgesic Activities of Newly Synthesized Chiral Peptide Derivatives Using (3‐Benzoyl‐ 4,5‐dioxo‐2‐phenyl‐pyrrolidin‐1‐yl)acetic Acid Ethylester as Starting Material
A series of heterocyclic derivatives was synthesized using (3‐benzoyl‐4,5‐dioxo‐2‐phenyl‐pyrrolidin‐1‐yl)acetic acid ethyl ester 1 as starting material. Treatment of 1 with 1 N NaOH or hydrazineExpand
  • 14
Synthesis and antimicrobial activities of 2-substituted 12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines, 3-ethoxycarbonyl-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine-2-one and ethyl
Preparation of 2-substituted 9-(diethylamino)-12-(4-chlorophenyl)-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines is reported. Furthermore,Expand
  • 18
Synthesis and Antimicrobial Activities of Some New Synthesized Imide and Schiff's Base Derivatives
A series of 2,6-bis(substituted thiazolopyrimi-dinyl) pyridine (2a,b) and corresponding Schiff's bases (3a–j) were synthesized fromExpand
  • 11