Nerges Winblad

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Targeting of multiple genomic loci with Cas9 is limited by the need for multiple or large expression constructs. Here we show that the ability of Cpf1 to process its own CRISPR RNA (crRNA) can be used to simplify multiplexed genome editing. Using a single customized CRISPR array, we edit up to four genes in mammalian cells and three in the mouse brain,(More)
1 Broad Institute of MIT and Harvard, Cambridge, MA 02142 2 McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139 3 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 4 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA(More)
In the version of this article initially published, in Fig. 2j, the percentage for the targets Mecp2, Nlgn3, and Drd1 should be 15.2%, not 16.9%; the same error appeared in the main text, next to last paragraph, “Our results show that ~17%...” should be “Our results show that ~15%....” In the Fig. 2 legend, KASH should be spelled out as “KASH, Klarsicht(More)
The ability to selectively edit targeted genome regions using a technique known as CRISPR–Cas editing has transformed many areas of biological research. These advances have raised the question of whether this technique will be used in the clinic in future to treat or prevent disease. Clinical trials using this technique to edit human cells are already under(More)
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