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Reactive Oxygen Species Generation Is Involved in Epidermal Growth Factor Receptor Transactivation through the Transient Oxidization of Src Homology 2-Containing Tyrosine Phosphatase in Endothelin-1…
Endothelin-1 (ET-1) is implicated in fibroblast proliferation, which results in cardiac fibrosis. Both reactive oxygen species (ROS) generation and epidermal growth factor receptor (EGFR)… Expand
Heme oxygenase-1 contributes to the cytoprotection of alpha-lipoic acid via activation of p44/42 mitogen-activated protein kinase in vascular smooth muscle cells.
- P. Cheng, Y. Lee, Neng-Lang Shih, Yao-Chang Chen, M. Yen
- Chemistry, Medicine
- Free radical biology & medicine
- 15 April 2006
Alpha-lipoic acid (ALA) is a natural antioxidant that scavenges reactive oxygen species (ROS) and regenerates or recycles endogenous antioxidants. ALA has recently been reported to protect against… Expand
Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced beta-myosin heavy chain gene expression and cardiomyocyte hypertrophy.
Endothelin-1 (ET-1) has been found to increase cardiac beta-myosin heavy chain (beta-MyHC) gene expression and induce hypertrophy in cardiomyocytes. ET-1 has been demonstrated to increase… Expand
Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts.
Endothelin-1 (ET-1) has been implicated in fibroblast proliferation. However, the mechanism involving ET-1 is not clear. The present study was performed to examine the role of endogenous ET-1 in… Expand
Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts.
- T. Cheng, P. Cheng, Neng-Lang Shih, I. Chen, D. Wang, J. Chen
- Journal of the American College of Cardiology
- 19 November 2003
OBJECTIVES The aim of this study was to investigate the effects of angiotensin II (Ang II) on fibroblast proliferation and endothelin-1 (ET-1) gene induction, focusing especially on reactive oxygen… Expand
Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy
- T. Cheng, J. Liu, +6 authors J. Chen
- Chemistry, Medicine
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 1 February 2004
Resveratrol is proposed to account in part for the protective effect of red wine on the cardiovascular system. Angiotensin II (Ang II) is a potent hypertrophic stimulus in cardiomyocytes. In this… Expand
Nitric Oxide Inhibits Endothelin-1-Induced Cardiomyocyte Hypertrophy through cGMP-mediated Suppression of Extracellular-Signal Regulated Kinase Phosphorylation
Cardiac hypertrophy is a compensatory mechanism in response to a variety of cardiovascular diseases. Recently, reactive oxygen species and nitric oxide (NO) have been demonstrated to be involved in… Expand
The Inhibitory Effect of Trilinolein on Norepinephrine-Induced β-Myosin Heavy Chain Promoter Activity, Reactive Oxygen Species Generation, and Extracellular Signal-Regulated Kinase Phosphorylation in…
The myocardial protective effects of trilinolein, isolated from the traditional Chinese herb Sanchi (Panax notoginseng), are thought to be related to its antioxidant activity. However, the… Expand
MECHANICAL STRETCH INDUCES ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE EXPRESSION IN NEONATAL RAT CARDIOMYOCYTES
- T. Cheng, J. J. Chen, +5 authors J. Chen
- Biology, Medicine
- Clinical and experimental pharmacology…
- 1 May 2009
1 Mechanical stretch leads to cardiac hypertrophy and may ultimately cause heart failure. However, the effect of mechanical stretch on gene induction in cardiomyocytes remains to be determined. 2 In… Expand
Sinugyrosanolide A, an unprecedented C-4 norcembranoid, from the Formosan soft coral Sinularia gyrosa.
- Shi-Yie Cheng, Neng-Lang Shih, +4 authors C. Duh
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 March 2014
Chemical investigations on the acetone extract of the Formosan soft coral Sinularia gyrosa have obtained a novel C-4 norcembranoid possessing an unprecedented tricyclo[220.127.116.11(3,8)]tetradecane… Expand