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Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, and population genetics studies with particular importance in the understanding of human population diversity and evolution. The aim of this study was to describe the HLA diversity in Mexican admixed individuals. We studied the(More)
Here, we present results for DPA1 and DPB1 four-digit allele-level typing in a large (n = 5,944) sample of unrelated European American stem cell donors previously characterized for other class I and class II loci. Examination of genetic data for both chains of the DP heterodimer in the largest cohort to date, at the amino acid epitope, allele, genotype, and(More)
A novel syntax-compliant encryption primitive and an efficient syntax-compliant JPEG 2000 encryption scheme are presented in this paper. The syntax-compliant encryption primitive takes, as input, syntax-compliant plaintext and produces syntax-compliant ciphertext. It is faster than all the other syntax-compliant encryption primitives we know. Our JPEG 2000(More)
The immune responses of natural killer cells are regulated, in part, by killer cell immunoglobulin-like receptors (KIR). The 16 closely-related genes in the KIR gene system have been diversified by gene duplication and unequal crossing over, thereby generating haplotypes with variation in gene copy number. Allelic variation also contributes to diversity(More)
BACKGROUND The development of breast cancer is multifactorial. Hormonal, environmental factors and genetic predisposition, among others, could interact in the presentation of breast carcinoma. Human leukocyte antigen (HLA) alleles play an important role in immunity (cellular immunity) and may be important genetic traits. HLAAllele-specific interaction has(More)
INTRODUCTION Human leukocyte antigen (HLA) polymorphism studies in Systemic Sclerosis (SSc) have yielded variable results. These studies need to consider the genetic admixture of the studied population. Here we used our previously reported definition of genetic admixture of Mexicans using HLA class I and II DNA blocks to map genetic susceptibility to(More)
Acknowledgment First of all, I would like to thank my advisor Professor Hao-hua Chu for providing a comfortable research environment and excellent laboratory equipments so that I can fully concentrate in my research. Furthermore, I would like to acknowledge your encouragement and understanding. I am very thankful to you for leading me to the(More)
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