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Accurate and scalable simulation has historically been a key enabling factor for systems research. We present TOSSIM, a simulator for TinyOS wireless sensor networks. By exploiting the sensor network domain and TinyOS's design, TOSSIM can capture network behavior at a high fidelity while scaling to thousands of nodes. By using a probabilistic bit error(More)
BACKGROUND There has been an outbreak of the severe acute respiratory syndrome (SARS) worldwide. We report the clinical, laboratory, and radiologic features of 138 cases of suspected SARS during a hospital outbreak in Hong Kong. METHODS From March 11 to 25, 2003, all patients with suspected SARS after exposure to an index patient or ward were admitted to(More)
OBJECTIVE To assess the acceptability of pre-pandemic influenza vaccination among healthcare workers in public hospitals in Hong Kong and the effect of escalation in the World Health Organization's alert level for an influenza pandemic. DESIGN Repeated cross sectional studies using self administered, anonymous questionnaires SETTING Surveys at 31(More)
BACKGROUND The goal of this study was to characterize viral loads and factors affecting viral clearance in persons with severe influenza. METHODS This was a 1-year prospective, observational study involving consecutive adults hospitalized with influenza. Nasal and throat swabs were collected at presentation, then daily until 1 week after symptom onset.(More)
BACKGROUND Community-acquired pneumonia (CAP) is a leading infectious cause of death throughout the world, including Hong Kong. AIM To compare the ability of three validated prediction rules for CAP to predict mortality in Hong Kong: the 20 variable Pneumonia Severity Index (PSI), the 6-point CURB65 scale adopted by the British Thoracic Society and the(More)
BACKGROUND Understanding factors affecting length of hospital stay (LOS) in patients with severe influenza may improve their management. METHODS A retrospective cohort study on laboratory-confirmed, adult influenza patients hospitalized in 2004 and 2005 was conducted. For all influenza cases during that period, immunofluorescence assay on nasopharyngeal(More)
Norovirus genogroup II genotype 4 (GII.4) has been the predominant cause of viral gastroenteritis since 1996. Here we show that during the winter of 2014-2015, an emergent variant of a previously rare norovirus GII.17 genotype, Kawasaki 2014, predominated in Hong Kong and outcompeted contemporary GII.4 Sydney 2012 in hospitalized cases. GII.17 cases were(More)
In Klebsiella pneumoniae liver abscess (KP-LA), K. pneumoniae K2 is the most frequently isolated serotype after K1, but this serotype has been much less studied. In the present study, the molecular types sequences type (MLST) of serotype K2 isolates from three different regions in Asia were identified and the virulence of these isolates was investigated.(More)
Antiviral therapy and vaccination are important strategies for controlling pandemic 2009 influenza A(H1N1) but efficacy depends on the timing of administration and is often limited by supply shortage. Patients with dyspnea, tachypnea, evidence of hypoxemia, and pulmonary infiltrates on chest radiograph should be hospitalized. Patients with severe illness or(More)
OBJECTIVES To evaluate the haematological findings of patients with severe acute respiratory syndrome (SARS). DESIGN Analysis of the demographic, clinical, and laboratory characteristics of patients with SARS. SETTING Prince of Wales Hospital, Hong Kong. Subjects All patients with a diagnosis of SARS between 11 March and 29 March 2003 who had no(More)