Nelson Adams

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Ethanol intake was explored in the Harrington derivation of the Maudsley Reactive and Maudsley Non-Reactive rat strains (MR/Har and MNRA/Har). When 5% and 10% ethanol solutions were presented as the sole source of fluid (1-bottle test), MR/Har rats, respectively, ingested 15% more, or 9% less, than their baseline water intake, whereas MNRAs ingested 6%(More)
Research on the Maudsley Reactive and Maudsley Nonreactive strains conducted primarily between 1980 and 2001 is reviewed. One line of research, which has found consistent differences between the Harrington derivation of the Maudsley Reactive (MR/Har) and Maudsley Nonreactive (MNRA/Har) strains in conflict situations, appears to support the traditional view(More)
OBJECTIVE Previous studies of ethanol (EtOH) intake under spontaneous choice conditions in Maudsley Reactive (MR) rats have demonstrated marked variability in EtOH preference. The present study investigated whether the social housing environment during the juvenile and early adult period would influence subsequent EtOH intake in male MR rats. METHODS Rats(More)
Repeated defeat by an aggressive resident attacker rat produces a large decrement in systolic blood pressure (SBP) in male S/JR rats. The present experiments compared the cardiovascular (CV) response of male S/JR rats exposed either to repeated defeat, or to a common laboratory stressor, electric foot-shock. Using the tail-cuff method of determining SBP,(More)
We studied the effects of social stress (SS) and a high salt diet on systolic blood pressure (SBP) and heart rate (HR): S/JR male rats (which exhibit marked elevations in SBP when placed on a high sodium diet) and R/JR male rats (which are resistant to the BP-elevating effects of a high sodium diet) were maintained on a low sodium diet (0.3% NaCl) or placed(More)
Genetic and maternal influences on hypertension were studied by comparing the SHR and SS/Jr inbred rat strains and their reciprocal F1 hybrids under identical conditions. When raised on a low salt (LS) diet (0.3% NaCl), SHR rats had higher systolic blood pressure (SBP) than SS/Jr rats by 9 weeks of age. Direct recordings from freely moving rats at 18-24(More)
We compared the ability of a high-NaCl diet to produce blood pressure elevation in spontaneously hypertensive rats (SHR) from the major North American commercial suppliers (Harlan, Taconic Farms, Charles River) and SHR and stroke-prone SHR (SHRSP) from the National Institutes of Health (NIH). Animals were raised on a low-NaCl diet containing 0.30% NaCl and(More)
Voluntary consumption of 10% ethanol (EtOH) vs. water was compared in EtOH-naive, male and female Maudsley Reactive (MR) inbred rats that were exposed to either daily episodes of tail pinch (TP), or no-stress controls for 35 consecutive days. Females drank significantly more EtOH than males as measured by preference for 10% EtOH vs. water, and for intake of(More)
The influence of the prenatal and postnatal maternal environment on stroke susceptibility was evaluated by reciprocally crossing the spontaneously hypertensive (SHR) and the Dahl salt-sensitive (SS/Jr) inbred rat strains to produce reciprocal F1 hybrids that were nurtured, respectively, during prenatal and postnatal life by SHR or SS/Jr mothers. Following(More)