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Signaling by the transcription factor nuclear factor kappa B (NF-kappaB) involves its release from inhibitor kappa B (IkappaB) in the cytosol, followed by translocation into the nucleus. NF-kappaB regulation of IkappaBalpha transcription represents a delayed negative feedback loop that drives oscillations in NF-kappaB translocation. Single-cell time-lapse(More)
In this paper, we present an algorithm for extracting keywords representing the asserted main point in a document, without relying on external devices such as natural language processing tools or a document corpus. Our algorithm KeyGraph is based on the seg-mentation of a graph, representing the co-occurrence between terms in a document, into clusters. Each(More)
The World Wide Web is a treasure trove of information. The Web's sheer scale m,l~.s automatic location and extraction of information appealing. However, much of the information lies bmied in documents designed for human consumption, such as home pages or product ~ta_Sogs. Before software agents can extract nuggets of infonnmion fi'om Web documents, they(More)
In previous work, we studied the behaviour of a model of part of the NF-kappaB signalling pathway. The model displayed oscillations that varied both in number, amplitude and frequency when its parameters were varied. Sensitivity analysis showed that just nine of the 64 reaction parameters were mainly responsible for the control of the oscillations when(More)
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