Nelly G Breeuwsma

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The lactase-phlorizin hydrolase gene is widely used as a marker of intestinal differentiation. Recent evidence demonstrating that transcription plays a major role in the regulation of this gene suggests that study of the 5'-flanking region will allow an understanding of how the expression of this gene is controlled. However, sequence, restriction, and(More)
OBJECTIVE To analyze the value for grading of a previously developed quantitative morphometric/cytometric multivariate grading model (consisting of the mean nuclear area of the 10 largest nuclei (MNA-10, mitotic activity index = MAI and Ki-67 area% = Ki-67) in two new independent test sets of urothelial carcinomas (UCs) of the urinary bladder and to(More)
Familial adenomatous polyposis (FAP) is characterized by the development of adenomas throughout the entire gastrointestinal tract. We describe a brother and sister with FAP who developed adenocarcinoma around the papilla of Vater. Incidence, premalignancy, treatment and the need for prophylactic endoscopy are discussed.
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