Nelly Barbot

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The secosteroid 1,25-dihydroxyvitamin D3 (1,25 (OH)2D3) is the major biologically active metabolite of vitamin D. Antitumor activity of this hormone has been observed on several cell lines and on breast cancer in vivo. The purpose of this in vitro study was to determine the possible effect of 1,25(OH)2D3 on glioma cells. Two glioma cell lines from rat (C6)(More)
Serum calcitonin (CT) was determined by radioimmunoassay, using two monoclonal antisera, in 22 women and two men, who had Hashimoto's thyroiditis as confirmed by echographic, immunological or cytological criteria; in 23 patients, serum CT levels were measured after intravenous infusion of pentagastrin (Pg). In 21 cases, basal and Pg stimulated serum CT(More)
This article describes a new approach to estimate F 0 curves using a B-Spline model characterized by a knot sequence and associated control points. The free parameters of the model are the number of knots and their location. The free-knot placement , which is a NP-hard problem, is done using a global MLE within a simulated-annealing strategy. The optimal(More)
In the speech processing field, stylization of fundamental frequency <i>F</i> <sub>0</sub> has been subjected to numerous works. Models proposed in the literature rely on knowledge stemming from phonology and linguistics. We propose an approach that deals with the issue of <i>F</i> <sub>0</sub> curve stylization requiring as few linguistic assumptions as(More)
AIMS To examine the advantage of systematic plasma iodine assays in establishing the thyroid function of patients with thyroid disorders. METHODS Iodine was determined by inductively coupled plasma mass spectrometry (ICPMS) in the plasma of 799 patients consulting for possible thyroid disorders, indicated by FT4 and TSH assays. RESULTS Plasma iodine was(More)
A pentagastrin stimulation test using a calcitonin (CT) immunoradiometric assay was performed in 38 healthy subjects and in the following 50 patients: 25 subjects from families with at least 2 known cases of medullary thyroid carcinoma (MTC), 11 subjects from families with apparently sporadic MTC, 2 pheochromocytoma carriers, 1 primary hyperparathyroidism,(More)
Retinoic acid (RA), the acid form of vitamin A, is shown to enhance the synthesis of nerve growth factor (NGF) in cultures of mouse L cells. Maximal stimulation was observed in cells growing in a serum-free medium supplemented with 10(-6)M RA during 48 h. The drug increased both the level of NGF mRNA and the amount of mature NGF protein secreted by the(More)
Calcitonin (CT) is the most sensitive tumor marker for medullary thyroid carcinoma available, but it lacks specificity. Chronic renal failure (CRF) is known to be associated with elevations of serum immunoreactive calcitonin. Using an immunoradiometric assay to detect only mature CT, we evaluated the basal CT level and its response to pentagastrin in 30(More)
In a voice transformation context, prosody transformation using parallel corpora is quite unrealistic as such corpora are difficult and also expensive to build. Based on this observation, we propose an approach for transforming prosody using non-parallel corpora thanks to the MLLR adaptation strategy. This methodology is applied to the joint transformation(More)
This article is interested in the problem of the linguistic content of a speech corpus. Depending on the target task, the phonological and linguistic content of the corpus is controlled by collecting a set of sentences which covers a preset description of phonological attributes under the constraint of an overall duration as small as possible. This goal is(More)