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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
A novel autophagy‐stimulatory function of BH3‐only proteins beyond their established role as apoptosis inducers is revealed and is revealed by competitively disrupting the interaction between Beclin‐1 and B cl‐2 or Bcl‐XL.
Induction of autophagy by spermidine promotes longevity
Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
Crosstalk between apoptosis, necrosis and autophagy.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Molecular definitions of autophagy and related processes
A panel of leading experts in the field attempts here to define several autophagy‐related terms based on specific biochemical features to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagic research.
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- L. Galluzzi, J. M. Bravo-San Pedro, G. Kroemer
- BiologyCell Death and Differentiation
- 19 September 2014
The Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
Regulation of autophagy by cytoplasmic p53
Evidence is provided of a key signalling pathway that links autophagy to the cancer-associated dysregulation of p53, which improved the survival of p 53-deficient cancer cells under conditions of hypoxia and nutrient depletion, allowing them to maintain high ATP levels.
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
This work shows that mitophagy, a selective type of autophagy targeting mitochondria for degradation, interfaces with mitochondrial biogenesis to regulate mitochondrial content and longevity in Caenorhabditis elegans and reveals a homeostatic feedback loop that integrates metabolic signals to coordinate the biogenesis and turnover of mitochondria.
Mechanisms of mitophagy in cellular homeostasis, physiology and pathology
In this Review, Tavernarakis and colleagues describe recent advances in delineating the molecular mechanisms that mediate mitophagy, and discuss the complex roles of this pathway in physiological and pathological contexts.