Neil Sutcliffe

Learn More
Recombinant human albumin expressed in Saccharomyces cerevisiae was compared with native human serum albumin in its physicochemical properties and in its use as a stabilizer in lyophilized preparations of thyroid-stimulating hormone (TSH), interleukin 15 (IL-15) and granulocyte colony-stimulating factor (G-CSF). Advantages of recombinant albumin include its(More)
The proinsulin-like immunoreactivity (PLI) content of traditional and highly purified bovine insulin preparations sold by three insulin manufacturers in the UK has been estimated by radioimmunoassay. We report the PLI content of 22 batches of traditional insulin products and 32 of highly purified insulin, marketed between March 1980 and March 1983.(More)
Human pituitary thyroid-stimulating hormone (TSH) has been analysed by reversed-phase high-performance liquid chromatography on Aquapore RP-300, a 300-A pore-size short-alkyl-chain silica packing, in sodium chloride-containing buffers. At poH 2.0, two clearly resolved peaks were observed corresponding in retention time to alpha and beta subunit of TSH. With(More)
A number of reversed-phase (RP) HPLC systems for the separation of gonadorelin (gonadoliberin, LHRH) and five therapeutically important analogues have been systematically examined. The selectivity of RP-HPLC has been compared with several micellar electrokinetic chromatographic (MEKC) systems and free solution capillary electrophoresis. RP-HPLC exhibits(More)
A number of RP-HPLC systems, including those prescribed in several official monographs, have been evaluated for separating oxytocin, the vasopressins, some clinically important analogues and two additional neurohypophyseal nonapeptides. The separation has been compared with capillary zone electrophoresis and micellar electrophoresis in four micellar(More)
1. The rate of passage of chromic oxide (Cr) was similar in the pony and rhinoceros. 2. Higher apparent amounts digested were found using 4N-HCl-insoluble ash (AIA) than those determined by Cr, but overall digestibilities were similar for the two species. 3. An abrupt increase in the starch content of the horse diets increased the number of faecal ciliate(More)
  • 1