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We are at an interesting time in the evolution of the EEG. Studies are opening the door to understanding the intrinsic neuronal properties and network operations responsible for the generation of EEG oscillations. I will review some of our knowledge regarding the physiology of the normal and abnormal EEG. Both epileptic and non-epileptic activity will be(More)
OBJECTIVE This study sought to elucidate the relation of clinical, neuropsychological, and seizure variables to chronic and postictal psychoses in patients with temporal lobe epilepsy. METHOD Forty-four patients with treatment-refractory temporal lobe epilepsy were given formal psychiatric evaluations; 29 patients had no psychiatric disorder or a(More)
BACKGROUND Routine EEGs in individuals with epilepsy have interictal spikes in 56% of cases. The availability of prolonged EEG has changed the use of EEG in the assessment of epilepsy. OBJECTIVE To determine the time to first epileptiform activity on EEG in patients with epilepsy. This data will help optimize the duration of electrographic assessment for(More)
In this article, we review periodic EEG patterns, which have been classified into four different types based on their interval duration (short or long) and topographic distribution (lateralized, bilaterally independent, or diffuse and synchronous). The four patterns are: (1) periodic lateralized epileptiform discharges; (2) bilateral independent periodic(More)
OBJECTIVE To evaluate the efficacy and safety of oxcarbazepine (OXC) as monotherapy for patients with uncontrolled partial seizures. METHODS A multicenter, double-blind, randomized, parallel-group, dose-controlled monotherapy trial compared OXC at 2400 mg/day with OXC at 300 mg/day in patients with uncontrolled partial-onset seizures previously receiving(More)
OBJECTIVE Cerebellar atrophy has been noted in patients with phenytoin exposure. This finding has been attributed by some investigators to seizures, but by others to phenytoin. Previous studies included patients with mental retardation and convulsive seizures. We undertook a study in a group of nonretarded patients with partial epilepsy to better elucidate(More)
This study investigated the use of three-dimensional fast low-angle shot (FLASH) imaging and computer-assisted morphometry for identifying hippocampal changes associated with unilateral temporal lobe seizures. Contiguous 3.1-mm coronal FLASH images were obtained in 28 patients with electroencephalographically verified left (n = 17) or right (n = 11)(More)
INTRODUCTION No detailed case studies report lateralised hypometabolism on positron emission tomography (PET) contralateral to the epileptogenic focus in temporal lobe epilepsy (TLE). MATERIAL AND METHODS We performed 18F fluorodeoxyglucose (FDG) PET in two intractable TLE patients. RESULTS One had right temporal interictal spikes on(More)
BACKGROUND The emergence of psychogenic seizures after surgery for epilepsy is not well recognized. OBJECTIVES To identify the frequency of psychogenic seizures in an 11-year surgical experience and to characterize the patients with this complication. METHODS Ninety-six patients underwent surgery for epilepsy between 1985 and 1996. The surgical database(More)